Cytokines and the immunopathology of the spondyloarthropathies.

被引：3

作者：

Braun J. ^{[1
]}

Sieper J. ^{[1
]}

机构：

[1] Department of Medicine, Rheumatology, Klinikum Benjamin Franklin, Free University, Hindenburgdamm 30, Berlin

来源：

Current Rheumatology Reports | 1999年 / 1卷 / 1期

关键词：

Ankylose Spondylitis; Synovial Fluid; Spondylitis; Rheumatol; Chlamydia Trachomatis;

D O I：

10.1007/s11926-999-0028-y

中图分类号：

学科分类号：

摘要：

In contrast to rheumatoid arthritis (RA), the triggering antigens are known in reactive arthritis (ReA) and Lyme arthritis. Thus, in these arthritides the antigen-specific T-cell response can be investigated in much detail and lessons possibly learned for other spondyloarthropathies (SpA) such as ankylosing spondylitis (AS) where T cells may well also play an important role in the pathogenesis. This article focusses on the immunopathology of the SpA, ReA, and AS with special reference to T cells and cytokines.

引用

页码：67 / 77

页数：10

共 387 条

[1]

Sieper J(1995)Pathogenesis of spondylarthropathies. Persistent bacterial antigen, autoimmunity, or both Arthritis Rheum 38 1547-1554

[2]

Braun J(1994)Chlamydia pneumoniae—a new causative agent of reactive arthritis and undifferentiated oligoarthritis Ann Rheum Dis 53 100-105

[3]

Braun J(1998)The detection of Chlamydia trachomatis but not Chlamydia pneumoniae in the synovium of patients with a range of rheumatic diseases Arthritis Rheum 41 845-854

[4]

Laitko S(1995)Amplification of plasmid and chromosome Chlamydia DNA in synovial fluid of patients with reactive arthritis and undifferentiated seronegative oligoarthropathies Arthritis Rheum 38 1005-113

[5]

Treharne J(1997)Nested PCR strategy simultaneously targeting DNA sequences of multiple bacterial species in inflammatory joint diseases. I. Screening of synovial fluid samples of patients with spondyloarthropathies and other arthritides J Rheumatol 24 1092-1100

[6]

Wilkinson NZ(1998)Bacteria-specific lymphocyte proliferation in peripheral blood in reactive arthritis and related disease Brit J Rheumatol. 37 520-524

[7]

Kingsley GH(1993)T cells are responsible for the enhanced synovial cellular immune response to triggering antigen in reactive arthritis Clin Exp Immunol 91 96-102

[8]

Sieper J(1997)Longitudinal investigation of bacterium-specific synovial lymphocyte proliferation in reactive arthritis and Lyme arthritis Brit J Rheumatol 37 784-788

[9]

Bas S(1994)The specific antibacterial proliferation of reactive arthritis synovial T cells is not due to their higher proportion of CD45RO+ cells compared to peripheral blood J Rheumatol 21 1702-1707

[10]

Griffais R(1996)HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related TCRBV gene segments. A study in patients with reactive arthritis Scand J Immunol 43 101-108

← 1 2 3 4 5 6 7 8 9 10 →