Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology - An update for the surgical oncologist

被引：16

作者：

Griffiths E.A. ^{[1
]}

Pritchard S.A. ^{[2
]}

Mapstone N.P. ^{[3
]}

Welch I.M. ^{[4
]}

机构：

[1] Department of General Surgery, The University Hospitals of Morecambe Bay NHS Trust, Royal Lancaster Infirmary, Lancaster LA1 4RP, Ashton Road

[2] Department of Histopathology, South Manchester University Hospitals NHS Trust, Wythenshawe Hospital, Manchester M23 9LT, South Moor Road

[3] Department of Pathology, The University Hospitals of Morecambe Bay NHS Trust, Royal Lancaster Infirmary, Lancaster LA1 4RP, Ashton Road

[4] Department of Gastrointestinal Surgery, South Manchester University Hospitals NHS Trust, Wythenshawe Hospital, Manchester M23 9LT, South Moor Road

来源：

World Journal of Surgical Oncology | / 4卷 / 1期

关键词：

Sentinel Node; Endoscopic Mucosal Resection; High Grade Dysplasia; Oesophageal Cancer; Circumferential Resection Margin;

D O I：

10.1186/1477-7819-4-82

中图分类号：

学科分类号：

摘要：

Adenocarcinoma of the oesophagus and gastro-oesophageal junction are rapidly increasing in incidence and have a well described sequence of carcinogenesis: the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. During recent years there have been changes in the knowledge surrounding disease progression, cancer management and histopathology specimen reporting. Tumours around the gastro-oesophageal junction (GOJ) pose several specific challenges. Numerous difficulties arise when the existing TNM staging systems for gastric and oesophageal cancers are applied to GOJ tumours. The issues facing the current TNM staging and GOJ tumour classification systems are reviewed in this article. Recent evidence regarding the importance of several histopathologically derived prognostic factors, such as circumferential resection margin status and lymph node metastases, have implications for specimen reporting. With the rising use of multimodal treatments for oesophageal cancer it is important that the response of the tumour to this therapy is carefully documented pathologically. In addition, several controversial and novel areas such as endoscopic mucosal resection, lymph node micrometastases and the sentinel node concept are being studied. We aim to review these aspects, with special relevance to oesophageal and gastro-oesophageal cancer specimen reporting, to update the surgical oncologist with an interest in upper gastrointestinal cancer. © 2006 Griffiths et al; licensee BioMed Central Ltd.

引用

共 121 条

[1]

Blot W.J., Devesa S.S., Kneller R.W., Fraumeni Jr. J.F., Rising incidence of adenocarcinoma of the esophagus and gastric cardia, Jama, 265, 10, pp. 1287-1289, (1991)

[2]

Branagan G., Davies N., Early impact of centralization of oesophageal cancer surgery services, Br J Surg, 91, 12, pp. 1630-1632, (2004)

[3]

Lerut T., Nafteux P., Moons J., Coosemans W., Decker G., De Leyn P., Van Raemdonck D., Quality in the surgical treatment of cancer of the esophagus and gastroesophageal junction, Eur J Surg Oncol, 31, 6, pp. 587-594, (2005)

[4]

Metzger R., Bollschweiler E., Vallbohmer D., Maish M., DeMeester T.R., Holscher A.H., High volume centers for esophagectomy: What is the number needed to achieve low postoperative mortality?, Dis Esophagus, 17, 4, pp. 310-314, (2004)

[5]

Gillison E.W., Powell J., McConkey C.C., Spychal R.T., Surgical workload and outcome after resection for carcinoma of the oesophagus and cardia, Br J Surg, 89, 3, pp. 344-348, (2002)

[6]

Guidance an Commissioning Cancer Services: Improving Outcomes in Upper Gastrointestinal Cancers, (2001)

[7]

Melville A., Morris E., Forman D., Eastwood A., Management of upper gastrointestinal cancers, Qual Health Care, 10, 1, pp. 57-64, (2001)

[8]

Guidelines for the diagnosis and management of Barrett's columnar-lined oesophagus, (2005)

[9]

Levine D.S., Haggitt R.C., Blount P.L., Rabinovitch P.S., Rusch V.W., Reid B.J., An endoscopic biopsy protocol can differentiate high-grade dysplasia from early adenocarcinoma in Barrett's esophagus, Gastroenterology, 105, 1, pp. 40-50, (1993)

[10]

Flejou J.F., Barrett's oesophagus: From metaplasia to dysplasia and cancer, Gut, 54, SUPPL. 1, (2005)

← 1 2 3 4 5 6 7 8 9 10 →