The STATs in cell stress-type responses

被引：38

作者：

Dudley A.C. ^{[1
]}

Thomas D. ^{[2
]}

Best J. ^{[1
]}

Jenkins A. ^{[1
]}

机构：

[1] The Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Melbourne, VIC

[2] The Peter McCallum Cancer Center, Melbourne, VIC

来源：

Cell Communication and Signaling | / 2卷 / 1期

关键词：

Genistein; Cellular Stress; Serine Phosphorylation; Hyperosmotic Stress; Cell Survival Pathway;

D O I：

10.1186/1478-811X-2-8

中图分类号：

学科分类号：

摘要：

In the early 1990's, a new cell signaling pathway was described. This new paradigm, now known as the JAK/STAT pathway, has been extensively investigated in immune-type cells in response to interferons and interleukins. However, recent evidence suggests that the JAK/STAT pathway also mediates diverse cellular responses to various forms of biological stress including hypoxia/reperfusion, endotoxin, ultraviolet light, and hyperosmolarity. The current literature describing the JAK/STAT pathway's role in cellular stress responses has been reviewed herein, but it is clear that our knowledge in this area is far from complete. © 2004 Doudley et al; licensee BioMed Central Ltd.

引用

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