Spatiotemporal Organization of Ras Signaling: Rasosomes and the Galectin SwitchRasosomes and the Galectin SwitchAshery, Yizhar, Rotblat, Elad-Sfadia, Barkan, Haklai, and Kloog

被引：56

作者：

Uri Ashery ^{[1
]}

Ofer Yizhar ^{[1
]}

Barak Rotblat ^{[1
]}

Galit Elad-Sfadia ^{[1
]}

Batya Barkan ^{[1
]}

Roni Haklai ^{[1
]}

Yoel Kloog ^{[1
]}

机构：

[1] George S. Wise Faculty of Life Sciences,Department of Neurobiochemistry

[2] Tel Aviv University,undefined

来源：

Cellular and Molecular Neurobiology | 2006年 / 26卷 / 4期

关键词：

ras; rasosomes; ras signaling; palmitoylation; galectin-1; galectin-3; prenyl-binding domains;

D O I：

10.1007/s10571-006-9059-3

中图分类号：

学科分类号：

摘要：

1. Ras signaling and oncogenesis depend on the dynamic interplay of Ras with distinctive plasma membrane (PM) microdomains and various intracellular compartments. Such interaction is dictated by individual elements in the carboxy-terminal domain of the Ras proteins, including a farnesyl isoprenoid group, sequences in the hypervariable region (hvr)-linker, and palmitoyl groups in H/N-Ras isoforms.

引用

页码：469 / 493

页数：24