Gene therapy for brain tumors.

被引：31

作者：

Bansal K. ^{[1
]}

Engelhard H.H. ^{[1
]}

机构：

[1] Departments of Neurosurgery and Molecular Genetics, College of Medicine, University of Illinois at Chicago, 912 South Wood Street, Chicago, 60612, IL

来源：

Current Oncology Reports | 2000年 / 2卷 / 5期

关键词：

Brain Tumor; Gene Therapy; Herpes Simplex; Malignant Glioma; Ganciclovir;

D O I：

10.1007/s11912-000-0067-z

中图分类号：

学科分类号：

摘要：

"Gene therapy" can be defined as the transfer of genetic material into a patient's cells for therapeutic purposes. To date, a diverse and creative assortment of treatment strategies utilizing gene therapy have been devised, including gene transfer for modulating the immune system, enzyme prodrug ("suicide gene") therapy, oncolytic therapy, replacement/therapeutic gene transfer, and antisense therapy. For malignant glioma, gene-directed prodrug therapy using the herpes simplex virus thymidine kinase gene was the first gene therapy attempted clinically. A variety of different strategies have now been pursued experimentally and in clinical trials. Although, to date, gene therapy for brain tumors has been found to be reasonably safe, concerns still exist regarding issues related to viral delivery, transduction efficiency, potential pathologic response of the brain, and treatment efficacy. Improved viral vectors are being sought, and potential use of gene therapy in combination with other treatments is being investigated.

引用

页码：463 / 472

页数：9

共 200 条

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