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Genetic Epidemiology of Psoriasis

被引：143
作者：
Gupta R. [1 ]
Debbaneh M.G. [1 ,2 ]
Liao W. [1 ]
机构：
[1] Department of Dermatology, University of California, San Francisco, San Francisco, CA, 94143
[2] School of Medicine, University of California, Irvine, Irvine, CA
来源：
Current Dermatology Reports | 2014年 / 3卷 / 1期
关键词：
Epidemiology; Genetic; Pathogenesis; Prevalence; Psoriasis;
D O I：
10.1007/s13671-013-0066-6
中图分类号：
学科分类号：
摘要：
Psoriasis is a chronic, inflammatory, immune-mediated skin condition with a prevalence of 0-11.8 % across the world. It is associated with a number of cardiovascular, metabolic, and autoimmune disease comorbidities. Psoriasis is a multifactorial disorder, influenced by both genetic and environmental factors. Its genetic basis has long been established through twin studies and familial clustering. The association of psoriasis with the HLA-Cw6 allele has been shown in many studies. Recent genome-wide association studies have identified a large number of other genes associated with psoriasis. Many of these genes regulate the innate and adaptive immune system. These findings indicate that a dysregulated immune system may play a major role in the pathogenesis of psoriasis. In this article, we review the clinical and genetic epidemiology of psoriasis with a brief description of the pathogenesis of disease. © 2014 Springer Science+Business Media New York.
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收藏
页码：61 / 78
页数：17
相关论文
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