Comparative efficacy of positron emission tomography and ultrasonography in preoperative evaluation of axillary lymph node metastases in breast cancer

被引:24
作者
Ohta M. [1 ]
Tokuda Y. [1 ]
Saitoh Y. [1 ]
Suzuki Y. [1 ]
Okumura A. [1 ]
Kubota M. [1 ]
Makuuchi H. [1 ]
Tajima T. [1 ]
Yasuda S. [1 ,2 ]
Shohtsu A. [2 ]
机构
[1] Department of Surgery, Tokai University, School of Medicine, Bohseidai
关键词
Axillary lymph node metastases; Breast cancer; PET;
D O I
10.1007/BF02967197
中图分类号
学科分类号
摘要
Purpose: In primary breast cancer, axillary nodal status is the most powerful predictive factor of recurrence. However, axillary lymph node dissection may cause surgical complications. If preoperative evaluation of axillary lymph node metastases is possible, unnecessary axillary lymph node dissections can be avoided. The purpose of this study was to evaluate the efficacy of positron emission tomography (PET) on detection of axillary lymph node metastases in breast cancer. Methods: PET scans of the axilla were obtained in 32 patients with primary breast cancer. All patients fasted for at least 4 hours before the examination. After transmission scans for attenuation correction were performed, emission scans after intravenous injection of 2-['SF]-fluoro-2-deoxy-D-glucose (FDG) were obtained. Results: Overall accuracy of PET alone, ultrasonography alone, and in combination in the detection of axillary metastases were 82%, 79%, and 85% respectively. Conclusion: There were no significant differences between PET, ultrasonography, and PET in combination with ultrasonography regarding sensitivity, specificity and accuracy in the detection of axillary metastases.
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页码:99 / 103
页数:4
相关论文
共 38 条
[1]  
Fisher B., Bauer M., Wickerham D.L., Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update, Cancer, 52, 9, pp. 1551-1557, (1983)
[2]  
Pezner R.D., Patterson M.P., Hill L.R., Arm lymphedema in patients treated conservatively for breast cancer: Relationship to patient age and axillary node dissection technique, International Journal of Radiation Oncology Biology Physics, 12, 12, pp. 2079-2083, (1986)
[3]  
Assa J., The intercostobrachial nerve in radical mastectomy, J Surg Oncol, 6, pp. 123-126, (1974)
[4]  
Warburg O., On the origin of cancer cells, Science, 123, pp. 309-314, (1956)
[5]  
Kubota R., Kubota K., Yamada S., Tada M., Ido T., Tamahashi N., Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake, Journal of Nuclear Medicine, 35, 1, pp. 104-112, (1994)
[6]  
Di Chiro G., Positron emission tomography using [ <sup>18</sup>F] fluorodeoxyglucose in brain tumors. A powerful diagnostic and prognostic tool, Investigative Radiology, 22, 5, pp. 360-371, (1987)
[7]  
Rege S., Maass A., Chaiken L., Hoh C.K., Choi Y., Lufkin R., Anzai Y., Juillard G., Maddahi J., Phelps M.E., Use of positron emission tomography with fluorodeoxyglucose in patients with extracranial head and neck cancers, Cancer, 73, 12, pp. 3047-3058, (1994)
[8]  
Laubenbacher C., Saumweber D., Wagener-Manslau C., Et al., Comparison of fluorine-18-fluorodeoxyglucose PET, MRI and endoscopy for staging of head and neck squamous-cell carcinomas, J Nucl Med, 36, pp. 1747-1757, (1995)
[9]  
Wahl R.L., Quint L.E., Greenough R.L., Meyer C.R., White R.I., Orringer M.B., Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: Preliminary prospective evaluation, Radiology, 191, 2, pp. 371-377, (1994)
[10]  
Lewis P., Griffin S., Marsden P., Et al., Whole-body 18Ffluorodeoxyglucose positron emission tomography in preoperative evaluation of lung cancer, Lancet, 344, pp. 1265-1266, (1994)