Evaluation of the microbial growth response to inorganic nanoparticles

被引：100

作者：

Williams D.N. ^{[1
]}

Ehrman S.H. ^{[1
]}

Holoman T.R.P. ^{[1
]}

机构：

[1] Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742

来源：

Journal of Nanobiotechnology | / 4卷 / 1期

关键词：

Gold Nanoparticles; Dynamic Light Scattering; Dynamic Light Scattering; Oxide Nanoparticles; Luria Bertani;

D O I：

10.1186/1477-3155-4-3

中图分类号：

学科分类号：

摘要：

In order to enhance the utilization of inorganic nanoparticles in biological systems, it is important to develop a fundamental understanding of the influence they have on cellular health and function. Experiments were conducted to test silica, silica/iron oxide, and gold nanoparticles for their effects on the growth and activity of Escherichia coli (E. coli). Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used to characterize the morphology and quantify size distribution of the nanoparticles, respectively. TEM was also used to verify the interactions between composite iron oxide nanoparticles and E. coli. The results from DLS indicated that the inorganic nanoparticles formed small aggregates in the growth media. Growth studies measured the influence of the nanoparticles on cell proliferation at various concentrations, showing that the growth of E. coli in media containing the nanoparticles indicated no overt signs of toxicity. © 2006 Williams et al; licensee BioMed Central Ltd.

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