Proteomics and diabetic nephropathy

被引：19

作者：

Merchant M.L. ^{[1
]}

Klein J.B. ^{[1
]}

机构：

[1] Core Proteomics Laboratory, University of Louisville, Louisville, KY 40202

来源：

Current Diabetes Reports | 2005年 / 5卷 / 6期

关键词：

Diabetic Nephropathy; Protein Spot; Diabetic Kidney; Diabetic Kidney Disease; Normal Urine;

D O I：

10.1007/s11892-005-0056-6

中图分类号：

学科分类号：

摘要：

Diabetes mellitus is acknowledged to be a group of metabolic diseases and heterogeneous in natural history, pathogenesis, response to treatment, and disease progression and remission. Diabetic nephropathy (DN) accounts for approximately 40% of all newly diagnosed cases of endstage renal disease. The complexity of diabetes and its complications requires a broad-based, unbiased, scientific approach such as proteomics. Recently, proteomics (the systematic analysis of protein identity, quantity, and function) has been applied to the study of DN. Proteomic investigations into diabetic kidney disease have identified new mechanisms of diabetic renal pathology, as well as potential urinary markers of DN. Other current proteomic advances in understanding DN include identifying the role of advanced glycation end products in decreased mitochondrial respiration and also the rapid development of mass spectrometric methods for protein and peptide markers of DN development and markers to pharmacologic therapies. Proteomic analysis has only recently been applied to the study of DN, yet it has shown substantial potential. Copyright © 2005 by Current Science Inc.

引用

页码：464 / 469

页数：5

共 30 条

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