Glucose metabolism and visceral fat in GH deficient adults: Two years of GH-replacement

被引：11

作者：

Carneiro Spina L.D. ^{[1
,2
]}

Soares D.V. ^{[1
]}

Resende de Lima Oliveira Brasil R. ^{[1
]}

Lobo P.M. ^{[1
]}

Conceição F.L. ^{[1
]}

Vaisman M. ^{[1
]}

机构：

[1] Serviço de Endocrinologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ

[2] Leblon 22430-220, Rio de Janeiro, RJ

来源：

Pituitary | 2004年 / 7卷 / 3期

关键词：

GH deficiency in adults; GH replacement; Glucose metabolism; Visceral fat;

D O I：

10.1007/s11102-005-5065-6

中图分类号：

学科分类号：

摘要：

The aim of this study was to evaluate the effect of 24 months of growth hormone (GH) replacement on glucose metabolism and visceral fat in 17 adults with GH deficiency: 9 men and 8 women; age 40 ± 1.8 yr. [range 20-61] and body mass index 25 ± 0.8 Kg/m2. Glucose metabolism was evaluated by a standard oral glucose tolerance test (OGTT), by the homeostatic model assessment (HOMA) insulin resistance index and by the insulin sensitivity index (ISI)-composite derived from the OGTT. Visceral fat was evaluated by CT scan. Twenty-four months of GH replacement induced an increase in the prevalence of abnormal glucose tolerance, with significant progressive increment in 2h-OGTT insulin levels at 3, 12 and 24 months (p = 0.005). Plasma glucose levels and ISI-composite did not alter during the study. HOMA-IR index increased only in the group of patients (n = 8) who had abnormal OGTT at 24 months (p = 0.012). Visceral fat reduced at month 12 and remained decreased until the end of the study (p = 0.009). In conclusion, the present study suggests that adults with GH deficiency after twenty-four months of GH replacement developed abnormal glucose tolerance, probably due to an increase in insulin resistance, associated with higher insulin levels, despite favorable alterations in body composition. © Springer Science + Business Media, Inc. 2005.

引用

页码：123 / 129

页数：6

共 46 条

[1]

Jorgensen J.O.L., Pedersen S.A., Thuesen L., Et al., Beneficial effects of growth hormone treatment in GH-deficient adults, Lancet, 1, pp. 1221-1224, (1989)

[2]

Salomon F., Cuneo R.C., Hesp R., Sonksen P.H., The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency, N Eng J Med, 321, pp. 1797-1803, (1989)

[3]

Binnerts A., Swart G.R., Wilson J.H., Et al., The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition, Clin Endocrinol (Oxf), 37, pp. 79-87, (1992)

[4]

Bengtsson B.-A., Eden S., Lonn L., Et al., Treatment of adults with growth hormone (GH) deficiency with recombinant human GH, J Clin Endocrinol Metab, 76, pp. 309-317, (1993)

[5]

Al Shoumer K.A.S., Page B., Thomas E., Murphy M., Beshyah S.A., Johnston D.G., Effects of four years' treatment with biosynthetic human growth hormone (GH) on body composition in GH-deficient hypopituitary adults, Eur J Endocrinol, 135, pp. 559-567, (1996)

[6]

Gibney J., Wallace J.D., Spinks T., Et al., The effects of 10 years of recombinant human growth hormone (GH) in adult gh-deficient patients, J Clin Endocrinol Metab, 84, pp. 2596-2602, (1999)

[7]

Davidson M.B., Effect of growth hormone on carbohydrate and lipid metabolism, Endocr Rev, 8, pp. 115-131, (1987)

[8]

Bratusch-Marrain P.R., Smith D., DeFronzo R.A., The effect of growth hormone on glucose metabolism and insulin secretion in man, J Clin Endocrinol Metab, 55, pp. 973-982, (1982)

[9]

Luft R., Cerasi E., Hamberg C.A., Studies on the pathogenesis of diabetes in acromegaly, Acta Endocrinol (Copenh), 56, pp. 593-607, (1967)

[10]

Chrisoulidou A., Beshyah S.A., Rutherford O., Et al., Effects of 7 years of growth hormone replacement therapy in hypopituitary adults, J Clin Endocrinol Metab, 85, pp. 3762-3769, (2000)

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