Assessing and predicting functional impairment in alzheimer's disease: The emerging role of frontal system dysfunction

被引：13

作者：

Boyle P.A. ^{[1
]}

机构：

[1] Department of Neurology, Alzheimer's Disease Center, Boston University School of Med., Boston, MA 02118

来源：

Current Psychiatry Reports | 2004年 / 6卷 / 1期

关键词：

Dementia; Neuropsychiatric Symptom; Executive Dysfunction; Dementia Severity; Geriatr Psychiatry;

D O I：

10.1007/s11920-004-0033-9

中图分类号：

学科分类号：

摘要：

Alzheimer's disease (AD) is associated with neuropsychologic and neuropsychiatric dysfunction and is a leading cause of disability among the elderly. Impairments in activities of daily living (ADL) contribute significantly to the disability reported among patients with AD and diminish quality of life for patients and their families. ADL assessment represents an important component of the diagnosis, tracking, and management of AD. Further, an understanding of the determinants of ADL dysfunction is critical for the early identification of individuals at risk for functional disability and for improved patient care. This manuscript reviews methods for assessing ADL in patients with AD and summarizes the available literature on the neuropsychologic and neuropsychiatric correlates of functional impairment in AD. The emerging role of frontal system dysfunction as an important determinant of ADL impairment is discussed, and recommendations for clinical practice and future research are provided. Copyright © 2004 by Current Science Inc.

引用

页码：20 / 24

页数：4

共 43 条

[1]

Aguero-Torres H.L., Fratiglioni L., Winblad B., Natural history of Alzheimer's disease and other dementias: Review of the literature in the light of the findings from the Kungsholmen Project, Int. J. Geriatr. Psychiatry, 13, pp. 755-766, (1998)

[2]

Sauvaget C., Yamada M., Fujiwara S., Et al., Dementia as a predictor of functional disability: A four-year follow-up study, Gerontology, 48, pp. 226-233, (2002)

[3]

Lawton M.P., Brody E.M., Assessment of older people: Self-maintaining and instrumental activities of daily living, Gerontologist, 9, pp. 179-186, (1969)

[4]

Gauthier S., Gelinas I., Gauthier L., Functional disability in Alzheimer's disease, Int. Psychogeriatr., 9, SUPPL., pp. 163-165, (1997)

[5]

Stern Y., Hesdorffer D., Sano M., Et al., Measurement and prediction of functional capacity in Alzheimer's disease, Neurology, 40, pp. 8-14, (1990)

[6]

Mitnitski A.B., Graham J.E., Mogilner A.J., Rockwood K., The rate of decline in function in Alzheimer's disease and other dementias, J. Gerontol. B. Psychol. Sci. Soc. Sci., 54, (1999)

[7]

Clyburn L.D., Stones M.J., Hadjistavropoulos T., Et al., Predicting caregiver burden and depression in Alzheimer's disease, J. Gerontol. B. Psychol. Sci. Soc. Sci., 55, (2000)

[8]

Severson M.A., Smith G.E., Tangalos E.G., Et al., Patterns and predictors of institutionalization in community-based dementia patients, J. Am. Geriatr. Soc., 42, pp. 181-185, (1994)

[9]

Yaffe K., Fox P., Newcomer R., Et al., Patient and caregiver characteristics and nursing home placement in patients with dementia, JAMA, 287, pp. 2090-2097, (2002)

[10]

Diagnostic and Statistical Manual of Mental Disorders, (2000)

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