Overview of the management of differentiated thyroid cancer

被引:41
作者
Fernandes J.K. [1 ]
Day T.A. [1 ]
Richardson M.S. [1 ]
Sharma A.K. [1 ]
机构
[1] The Medical Univ. of South Carolina, Charleston, SC 29425
关键词
Thyroid Cancer; Thyroid Carcinoma; Papillary Thyroid Carcinoma; Thyroid Nodule; Thyroid Stimulate Hormone;
D O I
10.1007/s11864-005-0012-3
中图分类号
学科分类号
摘要
Thyroid cancer is an uncommon tumor accounting for roughly 1% of all new malignancies. Differentiated (ie, papillary or follicular) thyroid carcinoma is usually asymptomatic, and frequently appears as a solitary thyroid nodule but few show cervical lymphadenopathy or metastasis to lung, bone, or liver. Fine needle aspiration (FNA) is recommended in the initial diagnostic test. Depending on the size of the lesion and other associated risk factors, most patients are treated with total or near total thyroidectomy. Postoperative radioiodine ablation is performed when tumor has a potential for recurrence. Recurrence rates and cancer-specific mortality is decreased by suppressing thyroid stimulating hormone (TSH). Long-term surveillance and follow-up with physical examination every 3 to 6 months for 2 years and then annually if patient remains cancer free. Whole body iodine scans are done every 12 months for follow-up until one negative scan (either withdrawal of thyroid hormone or rhodium complex [rh]-TSH). Thyroglobulin measurements (with antithyroglobulin antibodies) and ultrasound neck are suggested at 6 and 12 months and then annually if disease free. Copyright © 2005 by Current Science Inc.
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页码:47 / 57
页数:10
相关论文
共 54 条
[1]  
Mazzaferri E.L., Management of a solitary thyroid nodule, N. Engl. J. Med., 328, pp. 553-559, (1993)
[2]  
Jemal A., Tiwari R.C., Murray T., Et al., Cancer statistics, 2004, CA Cancer J. Clin., 54, pp. 8-29, (2004)
[3]  
Figge J.J.T., Gerasimov G., Thyroid cancer: A comprehensive guide to clinical mangement, Humana Press, pp. 85-116, (1999)
[4]  
Pacini F., Vorontsova T., Demidchik E.P., Et al., Post-Chernobyl thyroid carcinoma in Belarus children and adolescents: Comparison with naturally occurring thyroid carcinoma in Italy and France, J. Clin. Endocrinol. Metab., 82, pp. 3563-3569, (1997)
[5]  
Alsanea O., Wada N., Ain Y., Et al., Is familial nonmedullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series, Surgery, 128, pp. 1043-1050, (2000)
[6]  
Sherman S.I., Thyroid carcinoma, Lancet, 361, pp. 501-511, (2003)
[7]  
Rosai J., Rosai and Ackerman's Surgical Pathology, (2004)
[8]  
Lee T.I., Yang H.J., Lin S.Y., Et al., The accuracy of fine-needle aspiration biopsy and frozen section in patients with thyroid cancer, Thyroid, 12, pp. 619-626, (2002)
[9]  
Dragoiescu C., Hoekstra O.S., Kuik D.J., Et al., Feasibility of a randomized trial on adjuvant radio-iodine therapy in differentiated thyroid cancer, Clin. Endocrinol. (Oxf.), 58, pp. 451-455, (2003)
[10]  
Singer P.A., Cooper D.S., Daniels G.H., Et al., Treatment guidelines for patients with thyroid nodules and well-differentiated thyroid cancer, Arch. Intern. Med., 156, pp. 2165-2172, (1996)