Human papillomavirus Type 33 DNA in breast cancer in chinese

被引：60

作者：

Yu Y. ^{[1
,2
]}

Morimoto T. ^{[2
]}

Sasa M. ^{[3
]}

Okazaki K. ^{[4
]}

Harada Y. ^{[5
]}

Fujiwara T. ^{[5
]}

Irie Y. ^{[5
]}

Takahashi E.-I. ^{[5
]}

Tanigami A. ^{[5
]}

Izumi K. ^{[6
]}

机构：

[1] Department of Pathology, Shanghai First People's Hospital

[2] University of Tokushima, School of Medical Sciences, 3-18-15 Kuramoto-cho

[3] Tokushima Breast Care Clinic, Otsuka Pharmaceutical Co, Ltd

[4] Kunitomi Surgical Clinic of Okayama, Otsuka Pharmaceutical Co, Ltd

[5] Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd

[6] 2nd Department of Pathology, University of Tokushima, School of Medicine

来源：

Breast Cancer | 2000年 / 7卷 / 1期

关键词：

Breast cancer; Chinese; HPV33; PCR;

D O I：

10.1007/BF02967185

中图分类号：

学科分类号：

摘要：

Background: The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer. Methods: We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China. Results: DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer. Conclusions: Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.

引用

页码：33 / 36

页数：3

共 13 条

[1]

De Villiers, E.-M., Heterogeneity of the human papillomavirus group (1989) Journal of Virology, 63 (11), pp. 4898-4903

[2]

Band, V., Zajchowski, D., Kulesa, V., Human papillomavirus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements (1990) Proc Natl Acad Sci USA, 87, pp. 463-467

[3]

Di Lonardo, A., Venufi, A., Marcante, M.L., Human papillomavirus in breast cancer (1992) Breast Cancer Res Treat, 21, pp. 95-100

[4]

Bratthaner, G.L., Tavassoli, F.A., O'Leary, T.J., Etiology of breast carcinoma

[5]

No apparent role for papillomavirus type 6/11/16/18 (1992) Pathol Res Pract, 188, pp. 384-386

[6]

Wrede, D., Luqmani, Y., Coombes, R.C., Absence of HPV16 and 18 DNA in breast cancer (1992) Br J Cancer, 65, pp. 891-894

[7]

Gopalkrishna, V., Singh, U.R., Sodhani, P., Sharma, J.K., Hedau, S.T., Mandal, A.K., Das, B.C., Absence of human papillomavirus DNA in breast cancer as revealed by polymerase chain reaction (1996) Breast Cancer Research and Treatment, 39 (2), pp. 197-202

[8]

Jonjic, N., Mustac, E., Krstulja, M., Zamolo, G., Valkovic, T., Sasso, F., Bottin, C., Melato, M., Nuclear grade in invasive ductal breast carcinoma. Comparative study on nuclear grade and morphometric parameters, hormonal receptor status, flow cytometric analysis and lectin histochemistry (1996) General and Diagnostic Pathology, 142 (2), pp. 83-88

[9]

Beaudenon, S., Kremsdorf, D., Croissant, O., A novel type of human papillomavirus associated with genital neoplasias (1986) Nature, 321 (6067), pp. 246-249

[10]

Woodworth, C.D., Waggoner, S., Barnes, W., Human cervical and foreskin epithelial cells immortalized by human papillomavirus DNAs exhibit dysplastic differentiation in vivo (1990) Cancer Res, 50, pp. 3709-3716

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