The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: Progress to date and new avenues for discovery

被引：18

作者：

Aouizerat B.E.

Pearce C.L. ^{[1
]}

Miaskowski C. ^{[2
]}

机构：

[1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles

[2] Department of Physiological Nursing, University of California San Francisco, San Francisco

来源：

Current HIV/AIDS Reports | 2011年 / 8卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Disease progression; Genome-wide association study; GWAS; Single nucleotide polymorphism; SNP; Viral load set point;

D O I：

10.1007/s11904-010-0065-1

中图分类号：

学科分类号：

摘要：

Though pursuit of host genetic factors that influence the pathogenesis of HIV began over two decades ago, progress has been slow. Initial genome-level searches for variations associated with HIV-related traits have yielded interesting candidates, but less in the way of novel pathways to be exploited for therapeutic targets. More recent genome-wide association studies (GWAS) that include different phenotypes, novel designs, and that have examined different population characteristics suggest novel targets and affirm the utility of additional searches. Recent findings from these GWAS are reviewed, new directions for research are identified, and the promise of systems biology to yield novel insights is discussed. © 2011 The Author(s).

引用

页码：38 / 44

页数：6

共 38 条

[1]

An P., Winkler C.A., Host genes associated with HIV/AIDS: Advances in gene discovery, Trends Genet, 26, 3, pp. 119-131

[2]

Deng H., Liu R., Ellmeier W., Choe S., Unutmaz D., Burkhart M., Di M.P., Marmon S., Sutton R.E., Mark H.C., Davis C.B., Peiper S.C., Schall T.J., Littman D.R., Landau N.R., Identification of a major co-receptor for primary isolates of HIV-1, Nature, 381, 6584, pp. 661-666, (1996)

[3]

Dragic T., Litwin V., Allaway G.P., Martin S.R., Huang Y., Nagashima K.A., Cayanan C., Maddon P.J., Koup R.A., Moore J.P., Paxton W.A., HIV-1 entry into CD4 <sup>+</sup> cells is mediated by the chemokine receptor CC-CKR-5, Nature, 381, 6584, pp. 667-673, (1996)

[4]

Samson M., Libert F., Doranz B.J., Rucker J., Liesnard C., Farber C.M., Saragosti S., Lapoumeroulie C., Cognaux J., Forceille C., Muyldermans G., Verhofstede C., Burtonboy G., Georges M., Imai T., Rana S., Yi Y., Smyth R.J., Collman R.G., Doms R.W., Vassart G., Parmentier M., Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene, Nature, 382, 6593, pp. 722-725, (1996)

[5]

Dalmasso C., Carpentier W., Meyer L., Rouzioux C., Goujard C., Chaix M.L., Lambotte O., Avettand-Fenoel V., Le Clerc S., De Senneville L.D., Deveau C., Boufassa F., Debre P., Delfraissy J.F., Broet P., Theodorou I., Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: The ANRS Genome Wide Association 01 study, PLoS One, 3, 12, (2008)

[6]

Fellay J., Ge D., Shianna K.V., Colombo S., Ledergerber B., Cirulli E.T., Urban T.J., Zhang K., Gumbs C.E., Smith J.P., Castagna A., Cozzi-Lepri A., De Luca A., Easterbrook P., Gunthard H.F., Mallal S., Mussini C., Dalmau J., Martinez-Picado J., Miro J.M., Obel N., Wolinsky S.M., Martinson J.J., Detels R., Margolick J.B., Jacobson L.P., Descombes P., Antonarakis S.E., Beckmann J.S., O'Brien S.J., Letvin N.L., McMichael A.J., Haynes B.F., Carrington M., Feng S., Telenti A., Goldstein D.B., Commo

[7]

Fellay J., Shianna K.V., Ge D., Colombo S., Ledergerber B., Weale M., Zhang K., Gumbs C., Castagna A., Cossarizza A., Cozzi-Lepri A., De Luca A., Easterbrook P., Francioli P., Mallal S., Martinez-Picado J., Miro J.M., Obel N., Smith J.P., Wyniger J., Descombes P., Antonarakis S.E., Letvin N.L., McMichael A.J., Haynes B.F., Telenti A., Goldstein D.B., A whole-genome association study of major determinants for host control of HIV-1, Science, 317, 5840, pp. 944-947, (2007)

[8]

Herbeck J.T., Gottlieb G.S., Winkler C.A., Nelson G.W., An P., Maust B.S., Wong K.G., Troyer J.L., Goedert J.J., Kessing B.D., Detels R., Wolinsky S.M., Martinson J., Buchbinder S., Kirk G.D., Jacobson L.P., Margolick J.B., Kaslow R.A., O'Brien S.J., Mullins J.I., Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS, J Infect Dis, 201, 4, pp. 618-626

[9]

Joubert B.R., Lange E.M., Franceschini N., Mwapasa V., North K.E., Meshnick S.R., A whole genome association study of mother-to-child transmission of HIV in Malawi, Genome Med, 2, 3

[10]

Le Clerc S., Limou S., Coulonges C., Carpentier W., Dina C., Taing L., Delaneau O., Labib T., Sladek R., Group A.G., Deveau C., Guillemain H., Ratsimandresy R., Montes M., Spadoni J.L., Therwath A., Schachter F., Matsuda F., Gut I., Lelievre J.D., Levy Y., Froguel P., Delfraissy J.F., Hercberg S., Zagury J.F., Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03), J Infect Dis, 200, 8, pp. 1194-1201, (200

← 1 2 3 4 →