Role of endothelial cell survival and death signals in angiogenesis

被引：50

作者：

Nör J.E. ^{[1
,2
]}

Polverini P.J. ^{[1
,3
]}

机构：

[1] Dept. of Oral Med./Pathol./Oncology, Univ. of Michigan Sch. of Dentistry, Ann Arbor, MI

[2] Dept. Orthodontics and Pediat. Dent., Univ. of Michigan Sch. of Dentistry, Ann Arbor, MI

[3] Univ. of Michigan Sch. of Dentistry, 1011 N. University, Ann Arbor

来源：

Angiogenesis | 1999年 / 3卷 / 2期

基金：

美国国家卫生研究院;

关键词：

Angiogenesis; Apoptosis; Cell death; Endothelial cell; Neovascularization;

D O I：

10.1023/A:1009053411094

中图分类号：

学科分类号：

摘要：

Angiogenesis, the process of new microvessel development, is encountered in a select number of physiological processes and is central to the pathogenesis of a wide variety of diseases. There is now convincing evidence that regulated patterns of endothelial cell survival and death, a process known as apoptosis, play a central role in the periodic remodeling of the vasculature, and in the timely evolution and regression of angiogenic responses. In this review we discuss the current evidence suggesting a role for inducers and inhibitors of angiogenesis as well as other mediators that modify endothelial cells functions in the survival and death of endothelial cells. We also discuss how dysregulation of apoptosis can lead to aberrant angiogenesis as demonstrated in the pathogenesis of retinopathy of prematurity and cancer.

引用

页码：101 / 116

页数：15

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