Anaplastic large-cell lymphoma (Ki-1 lymphoma): Ultrastructural and immunohistochemical studies

被引：1

作者：

Hirano H. ^{[1
]}

Ichimura T. ^{[1
,2
]}

Hanibuchi M. ^{[3
,4
]}

Nakagawa M. ^{[3
]}

Maekura R. ^{[3
]}

Ito M. ^{[3
]}

Maeda T. ^{[5
]}

Yoshii Y. ^{[6
]}

Kuwabara H. ^{[6
]}

Mori H. ^{[6
]}

机构：

[1] Division of Pathology, Toneyama National Hospital, Toyonaka, Osaka 560-8552

[2] Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Kumamoto

[3] Division of Internal Medicine, Toneyama National Hospital, Osaka

[4] Third Department of Internal Medicine, The University of Tokushima School of Medicine, Tokushima

[5] Department of Technology, Kobe Tokiwa College, Hyogo

[6] Department of Pathology, Osaka Medical College, Osaka

来源：

Medical Electron Microscopy | 2002年 / 35卷 / 3期

关键词：

Anaplastic large cell lymphoma; Electron microscopy Immunohistochemistry; Ki-1-positive; Neutrophil-rich;

D O I：

10.1007/s007950200019

中图分类号：

学科分类号：

摘要：

We report an autopsy case of a malignant neutrophil-rich anaplastic large cell lymphoma (ALCL), which was reactive to the monoclonal antibody Ki-1 (CD30). This subtype of Ki-1 ALCL containing many neutrophils was named by Mann and colleagues in 1995, and its clinical and pathological characteristics have not been well described. In our case, the patient died 2 months after he first noticed an abdominal skin tumor. It was difficult to make the exact diagnosis of malignant lymphoma because the histological examination showed very poorly differentiated tumor cells. Ultrastructural observations revealed nuclei with convoluted contours and, sometimes, deep indentations, which suggested ALCL. Immunohistologically, most neoplastic cells were reactive with Ki-1 (CD30), leukocyte common antigen (LCA), and CD45RO (UCHL-1), and we confirmed Ki-1 ALCL. When we encounter poorly differentiated tumors on light microscopy, we should perform immunohistochemistry for hematological markers, such as LCA and Ki-1.

引用

页码：153 / 159

页数：6

共 49 条

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