Relationship between hyperuricemia and metabolic syndrome.

被引：30

作者：

Chen L.Y. ^{[1
]}

Zhu W.H. ^{[1
]}

Chen Z.W. ^{[1
]}

Dai H.L. ^{[1
]}

Ren J.J. ^{[1
]}

Chen J.H. ^{[1
]}

Chen L.Q. ^{[1
]}

Fang L.Z. ^{[1
]}

机构：

[1] Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou

来源：

Journal of Zhejiang University SCIENCE B | 2007年 / 8卷 / 8期

关键词：

Hyperuricemia; Metabolic syndrome; Triglyceride; R58;

D O I：

10.1631/jzus.2007.B0593

中图分类号：

学科分类号：

摘要：

OBJECTIVE: To investigate the relationship between metabolic syndrome and hyperuricemia. METHODS: A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as >or=7 mg/dl (in men) or >or=6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. RESULTS: (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia [odds ratio (OR)=1.634, P=0.000]. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia. CONCLUSION: Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome.

引用

页码：593 / 598

页数：5

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