Effect of acetylsalicylic acid on secondary metabolism ofCatharanthus roseus tumor suspension cultures

被引:36
作者
Gregorio Godoy-Hernández
Victor M. Loyola-Vargas
机构
[1] Centro de Investigación Científiíca de Yucatán,Departamento de Biología Experimental, División de Biología Vegetal
关键词
Acetylsalicylic acid; Aspirin; Alkaloids; suspension cultures; tumor;
D O I
10.1007/BF01088282
中图分类号
学科分类号
摘要
Addition of various concentrations (0.5–20 mM) of acetylsalicylic acid (ASA) to tumor lines ofCatharanthus roseus cultivatedin vitro and requiring corn starch as carbon source, produced remarkable effects on secondary metabolite production. An increase of 505% total alkaloids per culture (cells plus liquid medium), 1587% total phenolics (liquid medium), 612% total furanocoumarins (liquid medium) and 1476% total anthocyanins (liquid medium) was detected. 1 mM ASA in combination with other elicitors, such as homogenates ofAspergillus fumigatus or trans-cinnamic acid, did not further increase the metabolite content substantially. The results suggest that ASA could act as a new biotic elicitor of metabolite production inC. roseus cell suspension culture.
引用
收藏
页码:287 / 290
页数:3
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