Update on the diagnosis, treatment, and prognosis of the catastrophic antiphospholipid syndrome

被引：66

作者：

Cervera R. ^{[1
]}

机构：

[1] Department of Autoimmune Diseases, Servei de Malalties Autoimmunes, Hospital Clínic, Barcelona, Catalonia 08036

来源：

Current Rheumatology Reports | 2010年 / 12卷 / 1期

关键词：

Anticardiolipin antibodies; Antiphospholipid antibodies; Catastrophic antiphospholipid syndrome; Lupus anticoagulant;

D O I：

10.1007/s11926-009-0073-6

中图分类号：

学科分类号：

摘要：

The catastrophic antiphospholipid syndrome (APS) is a potentially life-threatening condition, the diagnosis of which requires a high degree of clinical awareness on the part of attending physicians. Patients with APS present with 1) clinical evidence of multiple organ involvement developed over a very short time; 2) histopathologic evidence of multiple small-vessel occlusions; and 3) laboratory confirmation of the presence of antiphospholipid antibodies, usually in high titer. A combination of anticoagulants, corticosteroids, intravenous immunoglobulins, and plasma exchanges is the basic treatment for all patients with this severe condition. Unfortunately, despite current therapies, the mortality rate is still high (around 30%). However, once patients with catastrophic APS have recovered, they usually follow a stable course with continued anticoagulation and few patients present with a relapse of the catastrophic episode. © 2009 Springer Science+Business Media, LLC.

引用

页码：70 / 76

页数：6

共 37 条

[1]

Asherson R.A., The catastrophic antiphospholipid antibody syndrome, J Rheumatol, 19, pp. 508-512, (1992)

[2]

Piette J.C., Cervera R., Levy R., Et al., The catastrophic antiphospholipid syndrome-Asherson's syndrome, Ann Med Intern, 154, pp. 95-96, (2003)

[3]

Asherson R.A., Cervera R., Piette J.-C., Font J., Lie J.T., Burcoglu A., Lim K., Munoz-Rodriguez F.J., Levy R.A., Boue F., Rossert J., Ingelmo M., Catastrophic antiphospholipid syndrome: Clinical and laboratory features of 50 patients, Medicine, 77, 3, pp. 195-207, (1998)

[4]

Asherson R.A., Cervera R., Piette J.-C., Shoenfeld Y., Espinosa G., Petri M.A., Lim E., Lau T.C., Gurjal A., Jedryka-GoRal A., Chwalinska-Sadowska H., Dibner R.J., Rojas-RodriGuez J., GarciA-Carrasco M., Grandone J.T., Parke A.L., Barbosa P., Vasconcelos C., Ramos-Casals M., Font J., Ingelmo M., Catastrophic antiphospholipid syndrome: Clues to the pathogenesis from a series of 80 patients, Medicine, 80, 6, pp. 355-377, (2001)

[5]

Bucciarelli S., Espinosa G., Cervera R., Erkan D., Gomez-Puerta J.A., Ramos-Casals M., Font J., Asherson R.A., Mortality in the catastrophic antiphospholipid syndrome: Causes of death and prognostic factors in a series of 250 patients, Arthritis and Rheumatism, 54, 8, pp. 2568-2576, (2006)

[6]

Cervera R., Piette J.-C., Font J., Khamashta M.A., Shoenfeld Y., Camps M.T., Jacobsen S., Lakos G., Tincani A., Kontopoulou-Griva I., Galeazzi M., Meroni P.L., Derksen R.H.W.M., De Groot P.G., Gromnica-Ihle E., Baleva M., Mosca M., Bombardieri S., Houssiau F., Gris J.-C., Quere I., Hachulla E., Vasconcelos C., Roch B., Fernandez-Nebro A., Boffa M.-C., Hughes G.R.V., Ingelmo M., Antiphospholipid syndrome: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1

[7]

Asherson R.A., Cervera R., De Groot P.G., Erkan D., Boffa M.-C., Piette J.-C., Khamashta M.A., Shoenfeld Y., Catastrophic antiphospholipid syndrome: International consensus statement on classification criteria and treatment guidelines, Lupus, 12, 7, pp. 530-534, (2003)

[8]

Cervera R., Font J., Gomez-Puerta J.A., Espinosa G., Cucho M., Bucciarelli S., Ramos-Casals M., Ingelmo M., Piette J.-C., Shoenfeld Y., Asherson R.A., Validation of the preliminary criteria for the classification of catastrophic antiphospholipid syndrome, Annals of the Rheumatic Diseases, 64, 8, pp. 1205-1209, (2005)

[9]

Cervera R., Bucciarelli S., Plasin M.A., Et al., Catastrophic antiphospholipid syndrome (CAPS): Descriptive analysis of a series of 280 patients from the "cAPS Registry, J Autoimmun, 32, pp. 240-245, (2009)

[10]

Espinosa G., Cervera R., Asherson R.A., Catastrophic antiphospholipid syndrome and sepsis. A common link?, Journal of Rheumatology, 34, 5, pp. 923-926, (2007)

← 1 2 3 4 →