New players in cytokine control of HIV infection

被引：44

作者：

Alfano M. ^{[1
]}

Crotti A. ^{[1
]}

Vicenzi E. ^{[1
]}

Poli G. ^{[1
]}

机构：

[1] P2/P3 Laboratories, DIBIT, 20132, Milano

来源：

Current HIV/AIDS Reports | 2008年 / 5卷 / 1期

关键词：

Natural Killer Cell; Long Terminal Repeat; Lipodystrophy; Immunologic Dysregulation;

D O I：

10.1007/s11904-008-0005-5

中图分类号：

学科分类号：

摘要：

Cytokines are involved early in the pathogenesis of HIV infection and disease progression as a component of immunologic dysregulation and immunodeficiency and as determinants controlling virus replication. Several steps, before and after retroviral integration into host DNA in T cells and macrophages, are affected by cytokines whereas CCR5 and CXCR4 binding chemokines can interfere with viral entry. A growing number of potential players - including the γ-common interleukin (IL)-7, IL-15, and IL-21 together with IL-17, IL-18, IL-19, IL-20, IL-23, and IL-27 - are discussed in terms of their perturbation in HIV infection and of their effects on virus replication. Thus, an increasing intersection of HIV infection and the cytokine network represents a crucial determinant of virus replication and immunologic dysregulation and will likely play a key role in the development of effective strategies of HIV prevention and immunologic reconstitution. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：27 / 32

页数：5

共 46 条

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