Cyclophosphamide-based combination therapies for autoimmunity

被引：3

作者：

Paola Perini

Massimiliano Calabrese

Luciano Rinaldi

Paolo Gallo

机构：

[1] University Hospital,Multiple Sclerosis Centre

来源：

Neurological Sciences | 2008年 / 29卷

关键词：

Cyclophosphamide; Combination therapy; Multiple sclerosis; Autoimmunity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Immunomodulatory agent (IMA)-unresponsive multiple sclerosis (MS) can quickly evolve to a dramatic and irreversible disability. Treating these patients with appropriate immunosuppressive therapies can be a chance to arrest disease activity and progression. Cyclophosphamide (Cyc)-based intense immunosuppression has been successfully used to treat rapidly deteriorating, IMA-refractory MS patients. Therapeutic protocols combining Cyc and interferon beta (IFNβ) have also been successfully applied to treat IFNβ-unresponsive MS. The association of Cyc with other immunomodulatory drugs or monoclonal antibodies is currently being investigated in clinical trials aimed at treating severe forms of autoimmune diseases.

引用

页码：233 / 234

页数：1

共 32 条

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