Coordination of copper with aspirin improves its anti-inflammatory activity

被引：7

作者：

Zhiqiang S. ^{[1
]}

Lei W.Y. ^{[1
]}

Li L. ^{[1
]}

Chen Z.H. ^{[1
]}

Liu W.P. ^{[1
]}

机构：

[1] Yunnan Pharmacol. Lab. of Nat. Prod., Kunming Medical College

来源：

InflammoPharmacology | 1998年 / 6卷 / 4期

关键词：

Anti-inflammatory activity; Aspirin; Copper aspirinate;

D O I：

10.1007/s10787-998-0018-0

中图分类号：

学科分类号：

摘要：

Anti-inflammatory activity of copper aspirinate administered orally was investigated in several models of inflammation. The results showed that copper aspirinate 50 mg/kg markedly inhibited inflammatory processes of either ear swelling induced by xylene in mice or turpentine-elicited air pouch granuloma in rats, with an activity equal to that of aspirin 200 mg/kg. Copper aspirinate 25 mg/kg significantly suppressed acute paw oedema produced by injecting 1% carrageenan, with an action time lasting over 6 h; and that copper aspirinate 100 mg/kg decreased the content of protein in the inflammatory exudate from rats with air pouch synovitis caused by acetic acid. It is suggested that, compared with aspirin, copper aspirinate showed a similar anti-inflammatory spectrum but greater anti-inflammatory activity.

引用

页码：357 / 362

页数：5

共 9 条

[1]

Smith EL, Hill RL, Leham IR, Lefkanitz RJ, Handler P, White A, Principals of Biochemistry: General Aspects and Mammalian Biochemistry, (1983)

[2]

Sorenson JRJ, Copper chelates as possible active forms of the antiarthritic agents, J Med Chem, 19, pp. 135-48, (1976)

[3]

Shen ZQ, Chen ZH, Ma GY, Wang DC, Wu WL., Inhibitory effects of copper-aspirin complex on platelet aggregation, Acta Pharmacol Sinica, 18, 4, pp. 358-62, (1997)

[4]

Tang XC, Lin ZG., Antiinflammatory effects of 3-acetylaconitine, Acta Pharmacol Sinica, 5, 2, pp. 85-9, (1984)

[5]

Winter CA, Risley E, Nuss G., Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs, Proc Soc Exp Biol Med, 111, pp. 544-7, (1962)

[6]

Kimura M, Kimura I, Luo B., Antiinflammatory effect of Japanese-Sino medicine, Keishi-Ka-jutsubu-to and its component drugs on adjuvant air pouch granuloma of mice, Phytother Res, 5, pp. 195-200, (1991)

[7]

Roch-Arveiber M, Huy DP, Maman L, Giroud JP, Sorenson JRJ, Non-steroidal anti-inflammatory drug-copper complex modulation of polymorphonuclear leukocyte migration, Biochem Pharmacol, 39, 3, pp. 569-74, (1990)

[8]

Sorenson JRJ, Rolniak TM., Preliminary chronic toxicity study of copper aspirinate, Inorg Chim Acta, 91, pp. L31-4, (1984)

[9]

Li L, Wu LO, Liu WP., Studies on the analgesic activity, toxicity and side effect of copper aspirin, Acad J Kunming Med Coll, 17, 4, pp. l-3, (1996)

← 1 →