B cells: new ways to inhibit their function in rheumatoid arthritis.

被引：1

作者：

Carter R.H. ^{[1
]}

机构：

[1] Department of Medicine, University of Alabama at Birmingham, 409 LHRB, 701 19th Street South, Birmingham, 35294, AL

来源：

Current Rheumatology Reports | 2004年 / 6卷 / 5期

基金：

美国国家卫生研究院;

关键词：

Rheumatoid Arthritis; Germinal Center; Marginal Zone; Follicular Dendritic Cell; Alefacept;

D O I：

10.1007/s11926-004-0010-7

中图分类号：

学科分类号：

摘要：

The apparent efficacy of B-cell depletion in autoimmune diseases has increased interest in targeting B cells. One goal of next generation therapies is to develop treatments that block B-cell activation and preserve resting nonautoimmune cells that maintain B cell memory. To do so, one needs to understand how B cells are activated and what receptors and intracellular signaling pathways regulate this process. This paper will summarize B-cell activation pathways and illustrate how these are being targeted in the development of new treatments for rheumatoid arthritis.

引用

页码：357 / 363

页数：6

共 224 条

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