Forecasting the cytokine storm following systematic interleukin (IL)-2 administration

被引：109

作者：

Panelli M.C. ^{[1
]}

White R. ^{[2
]}

Foster M. ^{[2
]}

Martin B. ^{[3
]}

Wang E. ^{[1
]}

Smith K. ^{[1
]}

Marincola F.M. ^{[1
]}

机构：

[1] Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD

[2] Carolinas Medical Center, Charlotte, NC

[3] Unit of Molecular Structure, National Institute of Mental Health, Bethesda, MD

来源：

Journal of Translational Medicine | / 2卷 / 1期

关键词：

Soluble Factor; Renal Cell Cancer; Cytokine Storm; Fourth Dose; Leukocyte Inhibitory Factor;

D O I：

10.1186/1479-5876-2-17

中图分类号：

学科分类号：

摘要：

Extensive clinical experience has shown that systemic interleukin (IL)-2 administration can induce complete or partial regression of renal cell cancer (RCC) metastases in 15 to 20 % of patients. Since IL-2 has no direct anti-cancer effects, it is believed that cancer regression is mediated either by a direct modulation of immune cell effector functions or through the mediation of soluble factors released as a result of IL-2 administration. We previously observed that transcriptional and protein changes induced by systemic IL-2 administration affect predominantly mononuclear phagocytes with little effect, particularly within the tumor microenvironment, on T cell activation, localization and proliferation. It further appeared that mononuclear phagocyte activation could be best explained by the indirect mediation of a secondary release of cytokines by IL-2 responsive cells either in the circulation or in peripheral tissues. © 2004 Panelli et al; licensee BioMed Central Ltd.

引用

页数：14

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