Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults

被引：61

作者：

Dixon B.M. ^{[1
]}

Barker T. ^{[2
]}

McKinnon T. ^{[1
]}

Cuomo J. ^{[1
]}

Frei B. ^{[3
]}

Borregaard N. ^{[4
]}

Gombart A.F. ^{[3
]}

机构：

[1] USANA Health Sciences Inc, Salt Lake City, UT 84120

[2] Sport Science Department, Orthopedic Specialty Hospital, Murray

[3] Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, Corvallis

[4] Granulocyte Research Laboratory, Department of Hematology, National University Hospital, Copenhagen

来源：

BMC Research Notes | / 5卷 / 1期

基金：

美国国家卫生研究院;

关键词：

25-hydroxyvitamin D; CAMP; Cathelicidin; hCAP18; Immunity; Infection; LL-37; Plasma; Serum; Vitamin D;

D O I：

10.1186/1756-0500-5-575

中图分类号：

学科分类号：

摘要：

Abstract. Background: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Significant levels of the protein hCAP18/LL-37 are found in the blood and may protect against infection and/or sepsis. We hypothesized that serum vitamin D levels may modulate the circulating levels of hCAP18. Only three studies have shown a positive correlation between circulating 25-hydroxyvitamin D and hCAP18 levels. Here we provide additional evidence for such a correlation in healthy, middle-aged adults. Findings. Serum levels of 25-hydroxyvitamin D [25(OH)D] and plasma levels of hCAP18 were determined in 19 healthy middle-aged (mean of 50.1 years) adult men and women. Plasma hCAP18 concentrations correlated with serum 25(OH)D concentrations in subjects with 25(OH)D levels ≤ 32 ng/ml (r = 0.81, p < 0.005) but not in subjects with concentrations > 32 ng/ml (r = 0.19, p = 0.63). Conclusions: We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D ≤ 32 ng/ml as opposed to those with concentrations > 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37. © 2012 Dixon et al.; licensee BioMed Central Ltd.

引用

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