What the emergency radiologist needs to know about treatment-related complications from conventional chemotherapy and newer molecular targeted agents

被引:11
作者
Sona A. Chikarmane
Bharti Khurana
Katherine M. Krajewski
Atul B. Shinagare
Stephanie Howard
Aaron Sodickson
Jyothi Jagannathan
Nikhil Ramaiya
机构
[1] Department of Emergency Radiology, Brigham and Women's Hospital, Boston, MA 02115
[2] Department of Imaging, Dana Farber Cancer Institute, Boston, MA 02115
关键词
Chemotherapy; Complications; Emergency; Molecular targeted therapy; Oncology;
D O I
10.1007/s10140-012-1052-1
中图分类号
学科分类号
摘要
Emergency departments (ED) are increasingly utilized by oncology patients for disease- and treatment-related issues. With the increased use of new molecular targeted therapy (MTT) and conventional chemotherapeutic regimens, oncology patients present with a range of adverse treatment effects, some of which reveal characteristic injury patterns and imaging appearances. Knowledge of these imaging findings is critically important for early detection and prompt management in oncology patients. In this article, we present a brief review of conventional chemotherapeutic and new MTT regimens as well as address adverse reactions that bring oncology patients to the ED. © Am Soc Emergency Radiol 2012.
引用
收藏
页码:535 / 546
页数:11
相关论文
共 38 条
[1]
Skeel R.T., Handbook of Cancer Chemotherapy, (2003)
[2]
Adelberg D.E., Bishop M.R., Emergencies related to cancer chemotherapy and hematopoietic stem cell transplantation, Emerg Med Clin North Am, 27, pp. 311-331, (2009)
[3]
Glass J.P., Lee Y.Y., Bruner J., Fields W.S., Treatment-related leukoencephalopathy, A Study of Three Cases and Literature Review. Medicine (Baltimore), 65, pp. 154-162, (1986)
[4]
Chu W.C., Lee V., Howard R.G., Roebuck D.J., Chik K.W., Li C.K., Imaging findings of paediatric oncology patients presenting with acute neurological symptoms, Clin Radiol, 58, pp. 589-603, (2003)
[5]
Agarwal A., Vijay K., Thamburaj K., Ouyang T., Transient leukoencephalopathy after intrathecal methotrexate mimicking stroke, Emerg Radiol, 18, pp. 345-347, (2011)
[6]
McKinney A.M., Short J., Truwit C.L., Et al., Posterior reversible encephalopathy syndrome: Incidence of atypical regions of involvement and imaging findings, AJR Am J Roentgenol, 189, pp. 904-912, (2007)
[7]
Hodnett P., Coyle J., O'Regan K., Maher M.M., Fanning N., PRES (posterior reversible encephalopathy syndrome), a rare complication of tacrolimus therapy, Emerg Radiol, 16, pp. 493-496, (2009)
[8]
Torrisi J.M., Schwartz L.H., Gollub M.J., Ginsberg M.S., Bosl G.J., Hricak H., CT findings of chemotherapy-induced toxicity: What radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity, Radiology, 258, pp. 41-56, (2011)
[9]
Duran I., Siu L.L., Oza A.M., Et al., Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus, Eur J Cancer, 42, pp. 1875-1880, (2006)
[10]
Van Glabbeke M., Verweij J., Casali P.G., Et al., Predicting toxicities for patients with advanced gastrointestinal stromal tumours treated with imatinib: A study of the European Organisation for Research and Treatment of Cancer, the Italian Sarcoma Group, and the Australasian Gastro-Intestinal Trials Group (EORTC-ISGAGITG), Eur J Cancer, 42, pp. 2277-2285, (2006)