The cell biology of parathyroid hormone in osteoblasts

被引：68

作者：

Kousteni S. ^{[1
]}

Bilezikian J.P. ^{[1
]}

机构：

[1] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032

来源：

Current Osteoporosis Reports | 2008年 / 6卷 / 2期

关键词：

Parathyroid Hormone; Osteoblastic Cell; Anabolic Effect; Osteoblast Apoptosis; Osteoblast Progenitor;

D O I：

10.1007/s11914-008-0013-9

中图分类号：

学科分类号：

摘要：

Continuous exposure to parathyroid hormone (PTH) is associated with catabolic effects, whereas intermittent exposure to low doses of PTH is associated with anabolic effects. By controlling osteoblast function, PTH increases bone formation on cancellous, endocortical, and periosteal bone surfaces. In general, PTH does not affect the replication of uncommitted osteoblast progenitors but suppresses proliferation of committed osteoprogenitors. Intermittent PTH promotes osteoblast differentiation, in part, by its ability to promote exit from the cell cycle, to activate Wnt signaling in osteoblasts, and to inhibit the Wnt antagonist sclerostin in osteocytes. Insulin-like growth factor-1 is also required for the actions of PTH to increase osteoblast numbers. Intermittent PTH prolongs osteoblast survival in rodents by mechanisms that involve activation and proteolytic degradation of Runx2. PTH's ability to orchestrate a dynamic range of signaling cascades that determine osteoblast fate may explain both its catabolic and beneficial actions on the skeleton. © Springer Science+Business Media, LLC 2008.

引用

页码：72 / 76

页数：4

共 38 条

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