The role of β2-adrenergic receptor variation in human Hypertension

被引：33

作者：

Bray M.S. ^{[1
]}

Boerwinkle E. ^{[1
]}

机构：

[1] Human Genetics Center, University of Texas, Houston Health Science Center, Houston, TX 77225

来源：

Current Hypertension Reports | 2000年 / 2卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Blood Pressure Level; Human Hypertension; Arg16Gly Polymorphism; Glu27 Allele; Gly16 Allele;

D O I：

10.1007/s11906-000-0056-5

中图分类号：

学科分类号：

摘要：

Hypertension results from a complex and diverse array of metabolic and physiologic processes that interact with environmental factors to ultimately determine blood pressure levels and disease. Consequently, the identification of genes related to hypertension is complicated by the heterogeneity of its etiology and the likelihood that several genes with moderate effects, possibly acting in a context-dependent manner, influence blood pressure and the occurrence of hypertension. A number of studies have recently implicated variation within the P2-adrenergic receptor in blood pressure regulation and the development of hypertension. The role of these findings is reviewed here, and their possible clinical implications in human hypertension. Copyright © 2000 by Current Science Inc.

引用

页码：39 / 43

页数：4

共 42 条

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