Prevalence of Helicobacter pylori infection in gastric remnant after distal gastrectomy for primary gastric cancer

被引：46

作者：

Onoda N. ^{[1
,2
]}

Maeda K. ^{[2
]}

Sawada T. ^{[2
]}

Wakasa K. ^{[3
]}

Arakawa T. ^{[4
]}

Chung K.H.-Y.-S. ^{[2
]}

机构：

[1] Department of Oncology, Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, 1-4-3, Asahi-machi

[2] Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka

[3] Department of Pathology, Osaka City University Hospital, Osaka

[4] Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka

来源：

Gastric Cancer | 2001年 / 4卷 / 2期

关键词：

Gastric cancer; Gastric remnant; Helicobacter pylori; Second primary cancer development;

D O I：

10.1007/PL00011729

中图分类号：

学科分类号：

摘要：

Background. The development of a second primary cancer in the gastric remnant after gastrectomy for early gastric carcinoma is a problem, and eradication of Helicobacter pylori after the operation has been recommended. However, to date, practical indications for H. pylori eradication after gastric cancer surgery have not yet been reported. Methods. We examined H. pylori infection in the gastric remnant after distal gastrectomy for primary gastric cancer. One hundred and nine patients who had had a gastrectomy were studied. Endoscopic findings and results from the urease test, bacteriologic assessment, serological test, and histopathological examination were analyzed. Results. Seventy-one patients (65.1%) were judged to be positive for H. pylori infection. The prevalence of H. pylori infection was found to be significantly decreased in older patients, patients in whom the operation had been performed a long time before examination, patients with symptoms, and patients with severe reflux gastritis. On the other hand, histologically, chronic and acute gastritis correlated significantly with H. pylori infection. H. pylori prevalence was highest in mildly atrophic mucosa and decreased with more extensive atrophic changes of the mucosa. Conclusions. The persistence of H. pylori-related active gastritis in the gastric remnant after gastric cancer surgery was suggested in younger patients with mild atrophic gastritis and without reflux gastritis. These patients may be the best candidates for H. pylori eradication therapy.

引用

页码：87 / 92

页数：5

共 29 条

[1]

Ichiyoshi Y., Toda T., Minamisono Y., Nagasaki S., Yakeishi Y., Sugimachi K., Recurrence in early gastric cancer, Surgery, 107, pp. 489-495, (1990)

[2]

Onoda N., Sato S., Maeda K., Katsuragi K., Aya M., Sawada T., Et al., Endoscopic detection of early carcinoma of the remnant stomach, Endosc Dig, 11, pp. 1531-1535, (1999)

[3]

Sowa M., Kato Y., Onoda N., Kubo T., Maekawa H., Nishimura M., Et al., Early cancer of the gastric remnant - With special emphasis on the importance of follow-up of gastrectomized patients, Hepato-gastroenterology, 39, pp. 400-404, (1992)

[4]

Sowa M., Onoda N., Nakanishi I., Maeda K., Yoshikawa K., Chung Y.S., Early stage carcinoma of the gastric remnant in Japan, Anti-cancer Res, 13, pp. 1835-1838, (1998)

[5]

Correa P., Human gastric carcinogenesis: A multistep and multifactorial process - First American Cancer Society award lecture on cancer epidemiology and prevention, Cancer Res, 52, pp. 6735-6740, (1992)

[6]

Warren J.R., Marshall B., Unidentified curved bacilli on gastric epithelium in active chronic gastritis, Lancet, 1, pp. 1273-1275, (1983)

[7]

Forman D., Newell D., Fullerton F., Yarnell J.W.G., Stacey A.R., Wald N., Sitas F., Association between infection with Helicobacter pylori and risk of gastric cancer: Evidence from a prospective investigation, BMJ, 302, pp. 1302-1305, (1991)

[8]

Parsonnet J., Friedman G.D., Vandersteen D.P., Chang Y., Vogelman J.H., Orentreich N., Sibley R.K., Helicobacter pylori infection and the risk of gastric carcinoma, N Engl J Med, 325, pp. 1127-1131, (1991)

[9]

Watanabe T., Tada M., Nagai H., Sasaki S., Nakao M., Helicobacter pylori infection induces gastric cancer in Mongolian gerbils, Gastroenterology, 115, pp. 642-648, (1998)

[10]

Honda S., Fujioka T., Tokieda M., Satoh R., Nishizono A., Nasu M., Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils, Cancer Res, 58, pp. 4255-4259, (1998)

← 1 2 3 →