Selenoprotein P

被引：57

作者：

Persson Moschos M. ^{[1
]}

机构：

[1] Division of Biomedical Nutrition, Center for Chemistry and Chemical Engineering, Lund University, SE-221 00 Lund

来源：

Cellular and Molecular Life Sciences CMLS | 2000年 / 57卷 / 13期

关键词：

Endothelial cells; Heparin-binding protein; Oxidant defense; Plasma; Selenium status; Selenocysteine; Selenoprotein P;

D O I：

10.1007/PL00000665

中图分类号：

学科分类号：

摘要：

Selenoprotein P (SeP) is an extracellular, monomeric glycoprotein containing up to 10 selenocysteine residues in the polypeptide chain. It is ubiquitously expressed in mammalian tissues, and in human plasma it accounts for at least 40% of the total selenium concentration. SeP binds to heparin and cell membranes, and is associated with endothelial cells. SeP in human plasma protects against peroxynitrite-mediated oxidation and reduces phospholipid hydroperoxide in vitro, in accordance with the presumption that it has a function as an extracellular oxidant defense. Immunochemical assays have demonstrated that its concentration in plasma varies much with selenium intake, but other factors also have an influence.

引用

页码：1836 / 1845

页数：9

共 65 条

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