Regulation of telomere movement by telomere chromatin structure

被引：25

作者：

Pandita T.K. ^{[1
]}

Hunt C.R. ^{[1
]}

Sharma G.G. ^{[1
]}

Yang Q. ^{[1
]}

机构：

[1] Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St. Louis

来源：

Cellular and Molecular Life Sciences | 2007年 / 64卷 / 2期

关键词：

ATM; Telomere binding factors; Telomere chromatin structure; Telomere movement; Telomere nuclear matrix interactions;

D O I：

10.1007/s00018-006-6465-0

中图分类号：

学科分类号：

摘要：

Beyond their role in replication and chromosome end capping, telomeres are also thought to function in meiotic chromosome pairing, meiotic and mitotic chromosome segregation as well as in nuclear organization. Observations in both somatic and meiotic cells suggest that the positioning of telomeres within the nucleus is highly specific and believed to be dependent mainly on telomere interactions with the nuclear envelope either directly or through chromatin interacting proteins. Although little is known about the mechanism of telomere clustering, some studies show that it is an active process. Recent data have suggested a regulatory role for telomere chromatin structure in telomere movement. This review will summarize recent studies on telomere interactions with the nuclear matrix, telomere chromatin structure and factors that modify telomere chromatin structure as related to regulation of telomere movement. © Birkhäuser Verlag, 2007.

引用

页码：131 / 138

页数：7

共 77 条

[1]

Pruss D., Reeves R., Bushman F.D., Wolffe A.P., The influence of DNA and nucleosome structure on integration events directed by HIV integrase, J. Biol. Chem, 269, pp. 25031-25041, (1994)

[2]

Pruss D., Bushman F.D., Wolffe A.P., Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core, Proc. Natl. Acad. Sci. USA, 91, pp. 5913-5917, (1994)

[3]

Wallrath L.L., Lu Q., Granok H., Elgin S.C., Architectural variations of inducible eukaryotic promoters: Preset and remodeling chromatin structures, Bioessays, 16, pp. 165-170, (1994)

[4]

Orten A.D., Tapscott S.J., Triplet repeat expansion in myotonic dystrophy alters the adjacent chromatin structure, Proc. Natl. Acad. Sci. USA, 92, pp. 5465-5469, (1995)

[5]

Wolffe A.P., Transcription: In tune with the histones, Cell, 77, pp. 13-16, (1994)

[6]

Wolffe A.P., Wong J., Pruss D., Activators and repressors: Making use of chromatin to regulate transcription, Genes Cells, 2, pp. 291-302, (1997)

[7]

Scherthan H., Telomere attachment and clustering during meiosis, (2006)

[8]

Taddei A., Gasser S.M., Multiple pathways for telomere tethering: Functional implications of subnuclear position for heterochromatin formation, Biochim. Biophys. Acta, 1677, pp. 120-128, (2004)

[9]

de Lange T., Protection of mammalian telomeres, Oncogene, 21, pp. 532-540, (2002)

[10]

Karlseder J., Broccoli D., Dai Y., Hardy S., de Lange T., p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2, Science, 283, pp. 1321-1325, (1999)

← 1 2 3 4 5 6 7 8 →