Clonally transmissible cancers in dogs and Tasmanian devils

被引：104

作者：

Murchison E.P. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Institute, Cambridge

来源：

Oncogene | 2008年 / 27卷 / Suppl 2期

关键词：

Allograft; CTVT; DFTD; Dog; Tasmanian devil; Transmissible cancer;

D O I：

10.1038/onc.2009.350

中图分类号：

学科分类号：

摘要：

Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are the only known naturally occurring clonally transmissible cancers. These cancers are transmitted by the physical transfer of viable tumor cells that can be transplanted across histocompatibility barriers into unrelated hosts. Despite their common etiology, DFTD and CTVT have evolved independently and have unique life histories and host adaptations. DFTD is a recently emerged aggressive facial tumor that is threatening the Tasmanian devil with extinction. CTVT is a sexually transmitted tumor of dogs that has a worldwide distribution and that probably arose thousands of years ago. By contrasting the biology, molecular genetics and immunology of these two unusual cancers, I highlight the common and unique features of clonally transmissible cancers, and discuss the implications of clonally transmissible cancers for host-pathogen evolution. © 2009 Macmillan Publishers Limited. All rights reserved.

引用

页码：S19 / S30

页数：11

共 127 条

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