Phenotyping central nervous system circuitry in chronic pain using functional MRI: Considerations and potential implications in the clinic

被引：20

作者：

Borsook D. ^{[1
,2
]}

Becerra L.

机构：

[1] P.A.I.N. Group, Brain Imaging Center, McLean Hospital, Belmont, MA 02478

[2] Athinoula A. Martinos Center for Biomedical Engineering, Massachusetts General Hospital, Harvard Medical School, Boston, MA

来源：

Current Pain and Headache Reports | 2007年 / 11卷 / 3期

关键词：

Chronic Pain; Neuropathic Pain; Irritable Bowel Syndrome; Functional Magnetic Resonance Imaging; Complex Regional Pain Syndrome;

D O I：

10.1007/s11916-007-0191-7

中图分类号：

学科分类号：

摘要：

Functional MRI (fMRI) has provided new insights into brain mechanisms in chronic pain. However, unlike acute pain measures in healthy volunteers, there are additional concerns relating to mapping brain circuits in these patients. These include the ability to measure evoked versus spontaneous pain, background conditions such as medications, or comorbid diseases such as depression, anxiety, or addiction. Nevertheless, our understanding of the centralization of pain with attendant changes in sensory, emotional, and autonomic function is being more clearly realized and has significant implications for defining the disease state and therapeutic interventions. It is possible that fMRI may become clinically useful. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：201 / 207

页数：6

共 65 条

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