Oxidative stress and atherosclerosis

被引：82

作者：

Schulze P.C. ^{[1
]}

Lee R.T. ^{[1
]}

机构：

[1] Cardiovascular Research, Partners Research Facility, Cambridge, MA 02139

来源：

Current Atherosclerosis Reports | 2005年 / 7卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Reactive Oxygen Species; NADPH Oxidase; Xanthine Oxidase; Arterioscler Thromb Vasc Biol; Neointimal Hyperplasia;

D O I：

10.1007/s11883-005-0013-5

中图分类号：

学科分类号：

摘要：

Understanding of the pathophysiology of atherosclerosis can provide new strategies for the prevention and treatment of patients with this common disease. Clinical, epidemiologic, and basic molecular science studies have identified oxidative stress as a factor contributing to the development and progression of atherosclerosis. Oxidative stress also participates in the pathogenesis of endothelial dysfunction and hypertension, two important factors in many patients with atherosclerosis. Further, it contributes to mechanisms of disease progression such as lipid oxidation and vascular remodeling. This article reviews the role of reactive oxygen species and oxidative stress in atherosclerosis. Copyright © 2005 by Current Science Inc.

引用

页码：242 / 248

页数：6

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