PASSCLAIM – Bone health and osteoporosis

被引：3

作者：

Ann Prentice

Jean-Philippe Bonjour

Francesco Branca

Cyrus Cooper

Albert Flynn

Michèle Garabedian

Detlef Müller

Daphne Pannemans

Peter Weber

机构：

[1] MRC Human Nutrition Research,

[2] Elsie Widdowson Laboratory,undefined

[3] Fulbourn Road,undefined

[4] Cambridge CB1 9NL,undefined

[5] UK,undefined

[6] Hôpitaux Universitaires de Genève,undefined

[7] Dept. de Medicine Interne,undefined

[8] Division de Maladies Oseuses,undefined

[9] Rue Micheli du Crest 24,undefined

[10] 1211 Geneva,undefined

[11] Switzerland,undefined

[12] Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN),undefined

[13] 00178 Rome,undefined

[14] Italy,undefined

[15] MRC Environmental Epidemiology Unit,undefined

[16] Southampton SO16 6YD,undefined

[17] UK,undefined

[18] University College,undefined

[19] Department of Food Science,undefined

[20] Technology & Nutrition,undefined

[21] Division of Nutritional Sciences,undefined

[22] Cork,undefined

[23] Ireland,undefined

[24] Hôpital Saint-Vincent de Paul,undefined

[25] Unité CNRS UPR 1524,undefined

[26] bat. CED,undefined

[27] 82,undefined

[28] Avenue Denfert-Rochereau,undefined

[29] 75014 Paris,undefined

[30] France,undefined

[31] Procter & Gamble European Service GmbH,undefined

[32] Zentrale Rechnungsprüfung,undefined

[33] Sulzbacher Str. 40,undefined

[34] 65824 Schwalbach am Taunus,undefined

[35] Germany,undefined

[36] ILSI Europe,undefined

[37] Avenue E. Mounier 83,undefined

[38] Box 6,undefined

[39] Brussels,undefined

[40] Belgium. publications@ilsieurope.be,undefined

[41] Roche Vitamins Ltd,undefined

[42] Human Nutrition and Health,undefined

[43] Grenzacherstrasse,undefined

[44] Bldg 93/832,undefined

[45] 4070 Basel,undefined

[46] Switzerland,undefined

来源：

European Journal of Nutrition | 2003年 / 42卷

关键词：

Key words bone health – bone mineral density – health claims – osteoporosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Background: The EC Concerted Action PASSCLAIM aims to produce a generic tool for assessing the scientific support for health-related claims for foods and food components. Aim: The task of the ITGB Working Group was to critically evaluate the categories of scientific evidence needed to support claims in relation to bone health and osteoporosis. Methods: A framework was developed to describe the chain of evidence that is required to link the consumption of a food or food component to bone health outcomes. Techniques available for interrogating each link in the chain were identified and their strengths and weaknesses considered. This framework was used to determine intermediate markers of health outcome with respect to osteoporosis and to debate the level of evidence that would be required to substantiate claims of enhanced function or reduced disease risk. Results: Use of this framework with osteoporotic fracture as the health endpoint resulted in the following judgements based on current knowledge: 1) bone mineral density (BMD) is an intermediate marker of bone health which, for people of any age and sex, can provide evidence of enhanced function; 2) for people over 50 years living in populations with a high incidence of fracture, BMD is an intermediate marker of osteoporotic fracture risk which can provide evidence of an increased probability of reduced disease risk; 3) because osteoporosis is defined as a state of increased fracture risk due to low bone mass and deterioration in bone microarchitecture, a claim of a definite reduction in osteoporosis or fracture risk requires similar substantiation to claims that fractures are prevented or treated, including clinical trials and animal studies; 4) data from lower in the chain of evidence, such as bone turnover and calcium bioavailability, are not, by themselves, sufficiently strongly related to bone health endpoints to provide evidence of enhanced function or reduced disease risk but can provide supporting information. Conclusions: In the light of existing scientific knowledge, a framework has been developed as a tool for considering the scientific support for claims relating to bone health and osteoporosis. To provide a working example, the framework has been used to assess the current position with osteoporotic fracture as the health endpoint. This experience will contribute to the formulation under PASSCLAIM of a generic tool for assessing the scientific support of health claims on foods.

引用

页码：i28 / i49