Markers to define ischemia: Are they ready for prime time use in patients with acute coronary syndromes?

被引：4

作者：

Adams J. ^{[1
]}

机构：

[1] University of Louisville, Division of Cardiology, Louisville, KY 40202

来源：

Current Cardiology Reports | 2004年 / 6卷 / 4期

关键词：

Ischemia; Acute Coronary Syndrome; Natriuretic Peptide; Unstable Angina; Major Adverse Cardiac Event;

D O I：

10.1007/s11886-004-0072-1

中图分类号：

学科分类号：

摘要：

Optimal treatment of patients who present with chest pain is predicated on accurate identification of those patients with a cardiac etiology of their discomfort. Serial troponins and electrocardiograms are very sensitive for the detection of myocardial infarction but they are insensitive for the detection of ischemia. There are many analytes that are being actively evaluated for routine use to facilitate the identification of patients with myocardial ischemia. At present, only one assay is US Food and Drug Administration-approved for the exclusion of ischemia; many other analytes are under clinical evaluation and are briefly reviewed. At present, none of these analytes are yet appropriate for routine clinical use. Copyright © 2004 by Current Science Inc.

引用

页码：253 / 258

页数：5

共 27 条

[1] Hamm C.W., Braunwald E., A classification of unstable angina revisited, Circulation, 102, pp. 118-122, (2000)
[2] Braunwald E., Antman E.M., Beasley J.W., Et al., ACC/AHA guidelines for the management of patients with unstable angina and non-ST segment elevation myocardial infarction, J. Am. Coll. Cardiol., 36, pp. 970-1062, (2000)
[3] Pope J.H., Selker H.P., Diagnosis of acute cardiac ischemia, Emerg. Med. Clin. North Am., 21, pp. 27-59, (2003)
[4] Selker H.P., Zalenski R.J., Antman E.M., Et al., An evaluation of technologies for identifying acute cardiac ischemia in the emergency department: A report from a National Heart Attack Alert Program working group, Ann. Emerg. Med., 29, pp. 13-87, (1997)
[5] Apple F.S., Quist H.E., Doyle P.J., Et al., Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations, Clin. Chem., 49, pp. 1331-1336, (2003)
[6] Libby P., Ridker P.M., Maseri A., Inflammation and atherosclerosis, Circulation, 105, pp. 1135-1143, (2002)
[7] Liuzzo G., Biasucci L.M., Rebuzzi A.G., Et al., Plasma protein acute-phase response in unstable angina is not induced by ischemic injury, Circulation, 94, pp. 2373-2380, (1996)
[8] Sabatine M.S., Morrow D.A., de Lemos J.A., Et al., Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: Simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide, Circulation, 105, pp. 1760-1763, (2002)
[9] Myocardial infarction redefined: A consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction, J. Am. Coll. Cardiol., 36, pp. 959-969, (2000)
[10] Antman E.M., Tanasijevic M.J., Thompson B., Et al., Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes, N. Engl. J. Med., 335, pp. 1342-1349, (1996)

← 1 2 3 →