Mesenchymal stem cell mechanobiology

被引：84

作者：

Castillo A.B. ^{[1
]}

Jacobs C.R. ^{[2
]}

机构：

[1] Bone and Joint Rehabilitation Research and Development Center, VA Palo Alto Health Care System, Mail Stop: 153, Palo Alto, CA 94304

[2] Biomedical Engineering, Columbia University, 351 Engineering Terrace, New York, NY 10027

来源：

Current Osteoporosis Reports | 2010年 / 8卷 / 2期

关键词：

Mechanotransduction; Mesenchymal stem cell; Osteogenic differentiation; Tissue regeneration;

D O I：

10.1007/s11914-010-0015-2

中图分类号：

学科分类号：

摘要：

Bone marrow-derived multipotent stem and stromal cells (MSCs) are likely candidates for cell-based therapies for various conditions including skeletal disease. Advancement of these therapies will rely on an ability to identify, isolate, manipulate, and deliver stem cells in a safe and effective manner. Although it is clear that physical signals affect tissue morphogenesis, stem cell differentiation, and healing processes, integration of mechanically induced signaling events remain obscure. Mechanisms underlying sensation and interpretation of mechanical signals by stem cells are the focus of intense study. External mechanical signals have the ability to activate osteogenic signaling pathways in MSCs including Wnt, Ror2, and Runx2. It is also clear that intracellular tensile forces resulting from cell-extracellular matrix interactions play a critical role in MSC regulation. Further work is required to determine the precise role that mechanical forces play in stem cell function. © Springer Science+Business Media, LLC 2010.

引用

页码：98 / 104

页数：6

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