Cytochrome P450s in flavonoid metabolism

被引：92

作者：

Ayabe S.-I. ^{[1
]}

Akashi T. ^{[1
]}

机构：

[1] Department of Applied Biological Sciences, Nihon University, Fujisawa, Kanagawa 252-8510

来源：

Phytochemistry Reviews | 2006年 / 5卷 / 2-3期

关键词：

Aliphatic hydroxylation; Aromatic hydroxylation; Flavonoid skeleton formation; Isoflavonoid; Phytoalexins;

D O I：

10.1007/s11101-006-9007-3

中图分类号：

学科分类号：

摘要：

In this review, cytochrome P450s characterized at the molecular level catalyzing aromatic hydroxylations, aliphatic hydroxylations and skeleton formation in the flavonoid metabolism are surveyed. They are involved in the biosynthesis of anthocyanin pigments and condensed tannin (CYP75, flavonoid 3′,5′-hydroxylase and 3′-hydroxylase), flavones [CYP93B, (2S)-flavanone 2-hydroxylase and flavone synthase II], and leguminous isoflavonoid phytoalexins [CYP71D9, flavonoid 6-hydroxylase; CYP81E, isoflavone 2′-hydroxylase and 3′-hydroxylase; CYP93A, 3,9-dihydroxypterocarpan 6a-hydroxylase; CYP93C, 2-hydroxyisoflavanone synthase (IFS)]. Other P450s of the flavonoid metabolism include methylenedioxy bridge forming enzyme, cyclases producing glyceollins, flavonol 6-hydroxylase and 8-dimethylallylnaringenin 2′-hydroxylase. Mechanistic studies on the unusual aryl migration by CYP93C, regulation of IFS expression in plant organs and its biotechnological applications are introduced, and flavonoid metabolisms by non-plant P450s are also briefly discussed. © 2006 Springer Science+Business Media B.V.

引用

页码：271 / 282

页数：11

共 86 条

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