Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: The NHLBI Family Heart Study

被引：32

作者：

Tang W. ^{[1
]}

Pankow J.S. ^{[1
]}

carr J.J. ^{[2
]}

Tracy R.P. ^{[3
]}

Bielinski S.J. ^{[1
]}

North K.E. ^{[4
]}

Hopkins P.N. ^{[5
]}

Kraja A.T. ^{[6
]}

Arnett D.K. ^{[7
]}

机构：

[1] Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN

[2] Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC

[3] Department of Pathology and Biochemistry, University of Vermont, Burlington, VT

[4] Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC

[5] Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT

[6] Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO

[7] Department of Epidemiology, School of Public Health, University of Alabama-Birmingham, Birmingham, AL

来源：

BMC Cardiovascular Disorders | / 7卷 / 1期

关键词：

Coronary Heart Disease; Coronary Artery Calcification; Coronary Artery Calcification Score; Generalize Estimate Equation; Agatston Score;

D O I：

10.1186/1471-2261-7-30

中图分类号：

学科分类号：

摘要：

Background: Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for subclinical atherosclerosis is less clear. In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis. Methods: CAC was measured using the Agatston score with multidetector computed tomography. Information on CAC and MCP-1 was obtained in 2246 whites and 470 African Americans (mean age 55 years) without a history of coronary heart disease (CHD). Information on sICAM-1 was obtained for white participants only. Results: In whites, after adjustment for age and gender, the odds ratios (ORs) of CAC (CAC < 0) associated with the second, third, fourth, and fifth quintiles of sICAM-1 compared to the first quintile were 1.22 (95% confidence interval [CI]: 0.91 - 1.63), 1.15 (0.84 - 1.58), 1.49 (1.09 - 2.05), and 1.72 (1.26 - 2.36) (p = 0.0005 for trend test), respectively. The corresponding ORs for the second to fifth quintiles of MCP-1 were 1.26 (0.92 - 1.73), 0.99 (0.73 - 1.34), 1.42 (1.03 - 1.96), and 2.00 (1.43 - 2.79) (p < 0.0001 for trend test), respectively. In multivariable analysis that additionally adjusted for other CHD risk factors, the association of CAC with sICAM-1 and MCP-1 was attenuated and no longer statistically significant. In African Americans, the age and gender-adjusted ORs of CAC associated with the second and third tertiles of MCP-1 compared to the first tertile were 1.16 (0.64 - 2.08) and 1.25 (0.70 - 2.23) (p = 0.44 for trend test), respectively. This result did not change materially after additional adjustment for other CHD risk factors. Test of race interaction showed that the magnitude of association between MCP-1 and CAC did not differ significantly between African Americans and whites. Similar results were obtained when CAC ≥ 10 was analyzed as an outcome for both MCP-1 and sICAM-1. Conclusion: This study suggests that sICAM-1 and MCP-1 are biomarkers of coronary atherosclerotic burden and their association with CAC was mainly driven by established CHD risk factors. © 2007 Tang et al; licensee BioMed Central Ltd.

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