Spongy matrix of hyaluronic acid and collagen as a cultured dermal substitute: Evaluation in an animal test

被引：36

作者：

K. Kubo

Y. Kuroyanagi

机构：

[1] Regenerative Tissue Engineering, Medical Sciences of Graduate School, Kitasato University, Sagamihara 228-8555

来源：

Journal of Artificial Organs | 2003年 / 6卷 / 1期

关键词：

Collagen; Cultured dermal substitute; Hyaluronic acid; Spongy matrix; Wound healing;

D O I：

10.1007/s100470300010

中图分类号：

学科分类号：

摘要：

The authors have developed a two-layered spongy matrix composed of hyaluronic acid (HA) and atelo-collagen (Col) as a cultured dermal substitute (CDS). This spongy matrix was applied to a full-thickness skin defect on the dorsum of Sprague-Dawley rats, and the wound conditions were observed over a period of 2 weeks. A piece of two-layered spongy matrix was applied to the wound, over which a commercially available polyurethane film dressing was applied. Both the macroscopic and the histological evaluations indicate that the two-layered spongy matrix is able to prepare a highly vascularized granulation tissue at an early stage. These findings suggest that this type of spongy matrix would be useful as a CDS.

引用

页码：64 / 70

页数：6

共 34 条

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