Bactericidal/permeability-increasing protein in host defense and its efficacy in the treatment of bacterial sepsis

被引：20

作者：

Ofer Levy

Peter Elsbach

机构：

[1] Children’s Hospital of Boston,Division of Infectious Diseases

来源：

Current Infectious Disease Reports | 2001年 / 3卷 / 5期

关键词：

Pediatric Intensive Care Unit; Meningococcal Sepsis; Bactericidal Permeability Increase; Lipopolysaccharide Binding Protein Level; Endotoxin Binding Protein;

D O I：

10.1007/BF03160475

中图分类号：

学科分类号：

摘要：

The 55-kD bactericidal/permeability-increasing protein (BPI) is a neutrophil-derived polypeptide belonging to a family of lipid and endotoxin binding proteins. BPI is composed of two functionally distinct structural domains: a potently antibacterial and antiendotoxin ∼ 20-kD aminoterminal half, and an opsonic carboxy-terminal portion. In multiple animal models, a recombinant amino-terminal fragment of BPI (rBPI21) is nontoxic and protects against gram-negative bacteria and endotoxin. In humans, rBPI21 is also nontoxic and nonimmunogenic and has undergone phase II/III clinical trials with apparent therapeutic benefit.

引用

页码：407 / 412

页数：5

共 189 条

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