Critical illness myopathy and polyneuropathy

被引：26

作者：

Bird S.J. ^{[1
]}

Rich M.M. ^{[1
]}

机构：

[1] Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, 19104, PA

来源：

Current Neurology and Neuroscience Reports | 2002年 / 2卷 / 6期

关键词：

Compound Muscle Action Potential Amplitude; Critical Care Neurology; Critical Illness; Critical Illness Myopathy; Systemic Inflammatory Response Syndrome;

D O I：

10.1007/s11910-002-0041-2

中图分类号：

学科分类号：

摘要：

Neuromuscular weakness commonly develops in the setting of critical illness. This weakness delays recovery and often causes prolonged ventilator dependence. An axonal sensory-motor polyneuropathy, critical illness polyneuropathy (CIP), is seen in up to one third of critically ill patients with the systemic inflammatory response syndrome (usually due to sepsis). An acute myopathy, critical illness myopathy (CIM), frequently develops in a similar setting, often in association with the use of corticosteroids and/or nondepolarizing neuromuscular blocking agents. These patients are often difficult to evaluate due to the limitations imposed by the critical care setting and may be further complicated by the presence of both CIP and CIM in varying degrees. This paper reviews the clinical and electrophysiologic features of these disorders, as well as the putative pathophysiology. In the case of CIM, an animal model has provided evidence that weakness in this disorder is caused by muscle membrane inexcitability due to altered membrane sodium currents and loss of myosin thick filaments. © 2002, Current Science Inc.

引用

页码：527 / 533

页数：6

共 44 条

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