Oxidative stress in congestive heart failure

被引：52

作者：

Singal P.K. ^{[1
]}

Khaper N. ^{[1
]}

Farahmand F. ^{[1
]}

Belló-Klein A. ^{[1
]}

机构：

[1] Institute of Cardiovascular Sciences, Department of Physiology, University of Manitoba, Winnipeg MB R2H 2A6

来源：

Current Cardiology Reports | 2000年 / 2卷 / 3期

基金：

英国医学研究理事会;

关键词：

Oxidative Stress; Heart Failure; Beta Carotene; Probucol; Redox Ratio;

D O I：

10.1007/s11886-000-0070-x

中图分类号：

学科分类号：

摘要：

Heart failure is considered to be a complex clinical syndrome, with alterations in the multiple neurohumoral systems and subcellular cardiac sites that correlate with abnormal cardiac function. Strong evidence for the role of oxidative stress in the pathogenesis of heart failure has been provided by studies on experimental animals as well as humans. This concept is gaining more acceptance due to the fact that during heart failure, changes in different neurohormones, cytokines, nitric oxide, and activated inflammatory cells are closely linked to oxidative stress at the cellular and molecular levels. The present article provides a simple description of oxygen free radicals as well as the antioxidant defense system. Evidence for the role of oxidative stress in the pathogenesis of heart failure is reviewed in a concise manner. Copyright © 2000 by Current Science Inc.

引用

页码：206 / 211

页数：5

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