Determination of interleukin-6 and tumor necrosis factor-alpha concentrations in Iranian-Khorasanian patients with preeclampsia

被引：44

作者：

Afshari J.T. ^{[1
]}

Ghomian N. ^{[2
]}

Shameli A. ^{[2
]}

Shakeri M.T. ^{[3
]}

Fahmidehkar M.A. ^{[1
]}

Mahajer F. ^{[1
]}

Khoshnavaz R. ^{[4
]}

Emadzadeh M. ^{[4
]}

机构：

[1] Immunogenetics Department, Immunology Research Group, Bu-Ali Research Institute, Mashhad, Bu-Ali Sq.

[2] Obstetrics and Gynecology Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Imam Reza Sq.

[3] Community Medicine Department, Medical School, Mashhad University of Medical Sciences, Mashhad, Daneshgah St.

[4] Department of Cardiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Ahmad Abad St.

来源：

BMC Pregnancy and Childbirth | / 5卷 / 1期

关键词：

Preeclampsia; Severe Preeclampsia; Endothelial Cell Damage; Normal Pregnant Woman; Preeclamptic Woman;

D O I：

10.1186/1471-2393-5-14

中图分类号：

学科分类号：

摘要：

Background: Our objective was to determine the role of Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF- alpha), markers of immune activation and endothelial dysfunction, in patients with preeclampsia. Methods: Twenty four women with preeclampsia and eighteen antepartum normotensive pregnant women were recruited as controls. Serum levels of IL-6 and TNF-alpha. were measured by enzyme-linked immunosorbent assay. We used independent-samples t test to assess the differences in the concentration of cytokines in preeclamptic patients and control subjects. Results: IL-6 levels [mean (S.D.)] were significantly higher in preeclamptic women [5.8 (4.85) pg/ml] compared to normal pregnant women [3.01 (2.45) pg/ml] (p=0.02). There was no significant change in concentration of TNF-alpha in preeclamptic women [53.8 (30.0) pg/ml] compared to normal pregnant women [51.9 (33.8) pg/ml] (p>0.1). Conclusions: The results of this study show that IL-6 as a pro-inflammatory cytokine is present in higher concentration in women with preeclampsia. The study was undertaken in women with established preeclampsia and it is not possible to determine whether the increased concentration of IL-6 is a cause or consequence of the disease. Furthermore, these findings suggest that serum TNF-alpha level is not associated with preeclampsia. © 2005 Tavakkol Afshari et al., licensee BioMed Central Ltd.

引用

页数：17

共 32 条

[1]

Vallance P., Collier J., Bhagat K., Infection, inflammation and infarction: Does acute endothelial dysfunction provide a link?, Lancet, 349, pp. 1391-1392, (1997)

[2]

Roberts J.M., Taylor R.N., Musci T.J., Rodgers G.M., Hubel C.A., McLaughlin M.K., Preeclampsia: An endothelial cell disorder, Am. J. Obstet. Gynecol., 161, pp. 1200-1204, (1989)

[3]

Stark J.M., Preeclampsia and cytokine induced oxidative stress, Br. J. Obstet. Gynecol., 100, pp. 105-109, (1993)

[4]

Nawroth P.P., Stern D.M., Modulation of endothelial cell hemostatic properties by tumor necrosis factor, J. Exp. Med., 163, pp. 740-745, (1986)

[5]

Akira S., Taga T., Kishimoto T., Interleukin-6 in biology and medicine, Adv. Immunol., 54, pp. 1-78, (1993)

[6]

Greer I.A., Lyall F., Perera T., Boswell F., Macara L.M., Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: A mechanism for endothelial dysfunction?, Obstet. Gynecol., 84, pp. 937-940, (1994)

[7]

Vince G.S., Starkey P.M., Austgulen R., Kwiatkowski D., Redman C.W.G., Interleukin-6, tumor necrosis factor and soluble tumor necrosis factor receptors in women with preeclampsia, Br. J. Obstet. Gynecol., 102, pp. 20-25, (1995)

[8]

Kupferminc M.J., Peaceman A.M., Aderka D., Wallach D., Socol M.L., Soluble tumor necrosis factor receptors and interleukin-6 levels in patients with severe preeclampsia, Obstet. Gynecol., 88, pp. 420-427, (1996)

[9]

Munno I., Chiechi L.M., Lacedra G., Berardesca C., Patimo C., Marcuccio L., Nardelli P., Loizzi P., Evaluation of nonspecific immunity and plasma levels of interferongamma, interleukin-6 and tumor necrosis factor-alpha in preeclampsia, Immunopharmacol. Immunotoxicol., 21, pp. 551-564, (1999)

[10]

Teran E., Escudero C., Moya W., Flores M., Vallance P., Lopez-Jaramillo P., Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with preeclampsia, Int. J. Gynecol. Obstet., 75, pp. 243-249, (2001)

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