Platelet-endothelial interactions in atherosclerosis.

被引：39

作者：

Sachais B.S. ^{[1
]}

机构：

[1] Department of Pathology and Laboratory Medicine, University of Pennsylvania, 207A John Morgan Building, 3620 Hamilton Walk, Philadelphia, 19104, PA

来源：

Current Atherosclerosis Reports | 2001年 / 3卷 / 5期

关键词：

Human Umbilical Vein Endothelial Cell; Platelet Activate Factor; Nimesulide; Platelet Adhesion; Arterioscler Thromb Vasc Biol;

D O I：

10.1007/s11883-001-0080-1

中图分类号：

学科分类号：

摘要：

The pathogenesis of atherosclerosis, the leading cause of morbidity and mortality in the United States, is multifactorial. Many factors that have been shown to influence the development of atherosclerosis also affect the function of the endothelium through soluble or cell-cell interactions. Among these, interactions between platelets and endothelial cells have only recently begun to receive systematic study. This article reviews recent evidence showing how the interaction between platelets and endothelial cells may play a important role in the pathogenesis of atherosclerosis, suggesting an underappreciated potential locus for pharmacologic intervention.

引用

页码：412 / 416

页数：4

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