Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers

被引:4
作者
Ya-Mei Yu
Weng-Cheng Chang
Chu-Sun Liu
Chingmin E. Tsai
机构
[1] Department of Nutrition, School of Medicine, China Medical College, Taichung
[2] School of Medicine, China Medical College, Taichung
[3] Dept. of Nutrition and Food Sciences, Fu Jen University, Taipei
[4] Dept. of Nutrition and Food Sciences, Fu Jen University
关键词
Adlay; Barley leaf; Hyperlipidemic smoker; LDL oxidation; Plasma lipids;
D O I
10.1023/B:QUAL.0000041159.81153.84
中图分类号
学科分类号
摘要
Forty hyperlipidemic patients, smokers and non-smokers, were studied. Subjects received 15 g young barley leaf extract (BL) or 60 g adlay daily for four weeks. The overnight fasting blood samples were drawn immediately prior to and after four weeks of supplementation. Blood samples were analyzed for plasma lipid profiles and their susceptibility to low-density lipoprotein (LDL) oxidation. The plasma total and LDL-cholesterol (LDL-C) levels were reduced following treatment with either BL or adlay. Furthermore, the lag phase of LDL oxidation increased after BL or adlay supplementation. However, it seemed that BL had stronger antioxidative effect on the prevention of LDL oxidation than adlay. These results also indicated that the antioxidative effect was less pronounced in smokers compared to non-smokers. Therefore, supplementation with BL or adlay can decrease plasma lipids and inhibit LDL oxidation, which may protect against atherosclerosis in hyperlipidemic smokers and/or non-smokers. © 2003 Kluwer Academic Publishers.
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页码:1 / 8
页数:7
相关论文
共 23 条
[1]
Toss R., Fuster V., The pathogenesis of atherosclerosis, Atherosclerosis and Coronary Artery Disease, pp. 441-460, (1996)
[2]
Witztum J.L., Steinberg D., Role of oxidized low-density lipoprotein in atherogenesis, J Clin Invest, 88, pp. 1785-1792, (1991)
[3]
Reilly M., Delanty N., Lawson J.A., Fitz Gerald G.A., Modulation of oxidant stress in vivo in chronic cigarette smokers, Circulation, 94, pp. 19-25, (1996)
[4]
Lykkesfeldt J., Loft S., Neilsen J.B., Ponlsen H.E., Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking, Am J Clin Nutr, 65, pp. 959-963, (1997)
[5]
Munro L.H., Barton G., Kelly F.J., Plasma RRR-tocopherol concentrations are lower in smokers than in non-smokers after ingestion of a similar oral load of this antioxidant vitamin, Clin Sci, 92, pp. 87-93, (1997)
[6]
Nishiyama T., Haglwara Y., Haglwara H., Shlbamoto T., Inhibitory effect of 2″-O-glycosyl isovitexin and α-tocopherol on genotoxic glyoxal formation in a lipid peroxidation system, Food Chem Toxic, 32, pp. 1047-1051, (1994)
[7]
Kaneda T., Hidaka Y., Kashiwai T., Tada H., Takano T., Nishiyamas M.K., Effect of coix seed on the changes in peripheral lymphocyte subsets, Rinsho Byori-Japanese, 40, pp. 179-181, (1992)
[8]
Numata M., Yamamto A., Moribayashi A., Yamada H., Antitumor components isolated from the Chinese herbal medicine coix lachryma-jobi, Planta Medica, 60, pp. 356-359, (1994)
[9]
Aoki M., Tuzihare N., Effect of the hatomngi (Coix lachryma-jobi L. var. ma-yuen) on the blood pressure, cholesterol absorption and serum lipid levels, Kaseigaku Zasshi, 35, pp. 89-96, (1984)
[10]
Taga M.S., Miller E.E., Pratt D.E., Chia seeds as a source of natural lipid antioxidants, J Am Oil Chem Soc, 61, pp. 928-931, (1984)