Epidemiology of fracture risk in the Women's Health Initiative

被引：19

作者：

Jackson R.D. ^{[1
]}

Donepudi S. ^{[1
]}

Mysiw W.J. ^{[1
]}

机构：

[1] Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH 43210

来源：

Current Osteoporosis Reports | 2008年 / 6卷 / 4期

关键词：

Bone Mineral Density; Fracture Risk; Clinical Risk Factor; Minority Woman; Bioavailable Testosterone;

D O I：

10.1007/s11914-008-0027-3

中图分类号：

学科分类号：

摘要：

Osteoporosis is one of the most disabling consequences of aging in women. Strategies that permit earlier identification of women at risk for fracture are needed. The Women's Health Initiative has extended our knowledge of clinical risk factors and biomarkers of fracture risk in postmenopausal women. Based upon 11 clinically available risk factors (age, race/ethnicity, self-reported health, weight, height, physical activity, parental hip fracture, fracture history after age 54, current smoking, corticosteroid use, and history of treated diabetes), an algorithm has been developed to predict 5-year hip fracture risk. Biomarkers including low vitamin D or bioavailable testosterone and/or high cystatin C or sex hormone-binding globulin also predict risk for hip fracture independent of clinical risk factors. To address the growing incidence of fractures in minority women, clinical risk factors for fracture have been identified. These data demonstrate that we can better identify women, irrespective of race or ethnicity, at risk for fracture. © Springer Science+Business Media, LLC 2008.

引用

页码：155 / 161

页数：6

共 30 条

[1]

Burge R., Dawson-Highes B., Solomon D.H., Et al., Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025, J Bone Miner Res, 21, pp. 465-475, (2006)

[2]

Magaziner J., Hawkes W., Hebel J.R., Et al., Recovery from hip fracture in eight areas of function, J Gerontol A Biol Sci Med Sci, 55, (2000)

[3]

VanStaa T.P., Dennison E.M., Leufkens H.E., Cooper C., Epidemiology of fractures in England and Wales, Bone, 29, pp. 517-522, (2001)

[4]

Sambrook P., Cooper C., Osteoporosis, Lancet, 367, pp. 2010-2018, (2006)

[5]

Marks R., Allegrante J.P., Mackenzie C.R., Lane J.M., Hip fractures among the elderly: Causes, consequences and control, Aging Res Rev, 2, pp. 57-93, (2003)

[6]

Heaney R.P., Remodeling and skeletal fragility, Osteoporos Int 2003, 14, SUPPL.

[7]

Johnell O., Kanis J.A., Oden A., Et al., Predictive value of bone mineral density for hip and other fractures, J Bone Miner Res, 20, pp. 1185-1194, (2005)

[8]

Wainwright S.A., Phipps K.R., Stone J.V., Et al., A large proportion of fractures in postmenopausal women occur with baseline bone mineral density T-score >= 2.5, J Bone Miner Res, 16, (2001)

[9]

Henry M.J., Pasco J.A., Seeman E., Et al., Assessment of fracture risk: Value of random population-based samples: The Geelong Osteoporosis Study, J Clin Densitom, 4, pp. 283-289, (2001)

[10]

Kanis J.A., Johnell O., Oden A., Et al., Risk of hip fracture according to World Health Organization criteria for osteopenia and osteoporosis, Bone, 27, pp. 585-590, (2000)

← 1 2 3 →