Protective effects upon experimental inflammation models of a polyphenol-supplemented virgin olive oil diet

被引：72

作者：

Martinínez-Domínguez E. ^{[1
]}

De la Puerta R. ^{[1
]}

Ruiz-Gutiérrez V. ^{[2
]}

机构：

[1] Departamento de Farmacología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, c/ Profesor Garcia Gonzalez s/n

[2] Instituto de la Grasa, (C.S.I.C.), 41012 Sevilla

来源：

Inflammation Research | 2001年 / 50卷 / 2期

关键词：

Diets; Inflammation; Polyphenols; Rheumatoid arthritis; Virgin olive oil;

D O I：

10.1007/s000110050731

中图分类号：

学科分类号：

摘要：

Objective and Design: The aim of the present study was to examine the effect of a virgin olive oil enriched diet in acute and chronic inflammation models in rats and to determine the effect of supplementing this oil with a higher content of its polyphenolic fraction. The response was compared to oils rich in monounsaturated fatty acids (high oleic sunflower oil and palm olein) and rich in polyunsaturated fatty acids (fish oil). Diets: Groups of 6-8 male Wistar rats were fed from weaning on six purified diets differing in type of oil: 2% corn oil (basal diet, BD), 15% high oleic sunflower oil (HOSO), 15% virgin olive oil (VOO), 15% virgin olive oil supplemented with 600 p.p.m. polyphenols from this oil (PSVOO), 15% palm olein (POL), and 15% fish oil (FO). Materials and methods: Rats were fed for 8 weeks with BD, HOSO, VOO, PSVOO, POL and FO diets before injecting carrageenan. Rats were fed for 3 weeks with BD, PSVOO and FO diets before induction of adjuvant arthritis. Dietary treatment with or without indomethacin continued during 3 weeks. The data were evaluated using an analysis of variance (ANOVA) followed by the least-significant differences. Results: In carrageenan oedema test, the inflammation indices of animals fed on a diet rich in olive oil (VOO) were lower compared to animals fed with oils high in oleic acid (HOSO, POL) and polyunsaturated fatty acids (FO), and markedly diminished in the group fed on PSVOO. In established adjuvant arthritis, the PSVOO diet was even more effective than FO diet in the prevention of inflammation. Both groups of animals showed an increase in weight during the latter days of the experiment compared to the BD. Indomethacin administered to every diet group, exerted a strong inhibitory effect on the inflammatory process throughout which was augmented by the PSVOO and FO diets. Conclusions: This study demonstrates that virgin olive oil with a higher content of polyphenolic compounds, similar to that of extra virgin olive oil, shows protective effects in both models of inflammation and improves the disease associated loss of weight. This supplementation also augmented the effects of drug therapy.

引用

页码：102 / 106

页数：4

共 41 条

[1]

Skoldstam L., Borjesson O., Kjallman A., Seiving B., Akesson B., Effect of six months of fish oil supplementation in stable rheumatoid arthritis. A double-blind, controlled study, Scand J Rheumatol, 21, pp. 178-185, (1992)

[2]

Calder P.C., N-3 polyunsaturated fatty acids and immune cell function, Advan Enzyme Regul, 37, pp. 197-237, (1997)

[3]

Donadio J.V., Grande J.P., Bergstralh E.J., Dart R.A., Larson T.S., Spencer D.C., The long-term outcome of patients with IgA nephropathy treated with fish oil in a controlled trial, J Am Soc Nephrol, 10, pp. 1772-1777, (1999)

[4]

Metha J.L., Lopez L.M., Lawson D., Wargovitch T.J., Williams L.L., Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease, Am J Med, 84, pp. 45-52, (1988)

[5]

Barradas M.A., Christofides J.A., Jeremy J.Y., Mikhailides D.P., Fry D.E., Dandona P., The effect of olive oil supplementation on human platelet function, serum cholesterol-related variables and plasma fibrinogen concentration: A pilot study, Nutr Res, 10, pp. 403-411, (1990)

[6]

Ziboh V.A., Cohen K.A., Ellis C.N., Miller C., Hamilton T.A., Kragballe K., Et al., Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids, Arch Dermatol, 122, pp. 1277-1282, (1986)

[7]

Fischer S., Dietary polyunsaturated fatty acids and eicosanoid formation in human, Adv Lipid Res, 23, pp. 169-198, (1989)

[8]

Lee T.H., Hoover R.L., Williams J.D., Sperling R.I., Ravalese III Jr., Spur B.W., Et al., Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function, N England J Med, 312, pp. 1217-1224, (1985)

[9]

Keys A., Mediterranean diet and public health: Personal reflections, Am J Clin Nutr, 61, (1995)

[10]

Andriamampandry M.D., Leray C., Gutbier G., Freund M., Cassel D., Cazenave J.P., Et al., Diets rich in saturated n-9 and n-3 fatty acids differentially affect the fatty acid composition of phospholipids and function of rat platelets, Platelets, 7, pp. 269-276, (1996)

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