Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris

被引：52

作者：

Leyden J.J. ^{[1
]}

Berger R.S. ^{[2
]}

Dunlap F.E. ^{[3
]}

Ellis C.N. ^{[4
]}

Connolly M.A. ^{[5
]}

Levy S.F. ^{[6
,7
]}

机构：

[1] Department of Dermatology, Univ. of Pennsylvania Health System, Philadelphia, PA

[2] Hill Top Research, Inc., East Brunswick, NJ

[3] Argus Research Inc., Tucson, AZ

[4] Department of Dermatology, University of Michigan, Medical School, Ann Arbor, MI

[5] ShellSTAT, Inc., Marion Station, MD

[6] Dermik Laboratories, Inc., Berwyn, PA

[7] Clin. Research and Medical Affairs, Dermik Laboratories, Inc, Berwyn, PA

来源：

American Journal of Clinical Dermatology | 2001年 / 2卷 / 1期

关键词：

Acne; Clindamycin; Benzoyl Peroxide; Tretinoin; Combination Product;

D O I：

10.2165/00128071-200102010-00006

中图分类号：

学科分类号：

摘要：

Background: Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris. When used in combination, they promise greater efficacy than either individual agent used alone and the combined use of benzoyl peroxide with topical antibacterials has been shown to decrease the emergence of antibacterial resistant species. Objective: The objective was to determine the efficacy and safety of a combination benzoyl peroxide plus clindamycin in a gel formulation compared with each of its 2 active constituents in gel vehicle, and gel vehicle given alone in the treatment of acne vulgaris. Methods: In this 10-week, multicenter, double-blind trial, 480 patients with moderate to moderately severe acne were randomized to receive twice-daily treatment with 5% benzoyl peroxide plus 1% clindamycin, 5% benzoyl peroxide, 1% clindamycin, or vehicle. Results: Significantly greater reductions in the number of inflammatory and total lesions were demonstrated in patients using combination therapy compared with those using any of its 3 individual components. Likewise, both physicians' and patients' global evaluations showed significantly greater improvements with the combination therapy than with its individual components. The most frequent adverse effect, dry skin, occurred to a similar extent in the combination and benzoyl peroxide treatment groups. Conclusion: The improved efficacy obtained with the combination therapy was accompanied by a tolerability profile similar to that of benzoyl peroxide alone, making this new combination product an alternative antimicrobial therapy for acne vulgaris.

引用

页码：33 / 39

页数：6

共 3 条

[1]

Chu A., Huber F.J., Plott R.T., The comparative efficacy of benzoyl peroxide 5%/erythromycin 3% gel and erythromycin 4%/zinc 1.2% solution in the treatment of acne vulgaris, Br J Dermatol, 136, pp. 235-238, (1997)

[2]

Richter J.R., Forstrom L.R., Kiistala U.O., Et al., Efficacy of the fixed 1.2% clindamycin phosphate, 0.025% tretinoin gel formulation (Velac) and a proprietary 0.025% tretinoin gel formulation (Aberela) in the topical control of facial acne, J Eur Acad Dermatol Venereol, 11, pp. 227-233, (1998)

[3]

Korting H., Braun-Falco O., Efficacy and tolerability of combined topical treatment of acne vulgaris with tretinoin and erythromycin in general practice, Drugs Exp Clin Res, 15, pp. 447-451, (1989)

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