The end of evidence-based medicine?

被引：15

作者：

Clark D.A. ^{[1
,2
]}

机构：

[1] Departments of Medicine, Faculty of Graduate Studies, McMaster University, Hamilton, ON L8S 4K1

[2] Affiliate Scientist Toronto General Research Institute, Toronto, ON

来源：

Inflammopharmacology | 2012年 / 20卷 / 4期

关键词：

Evidence-based medicine; Observational studies; Results-based medicine;

D O I：

10.1007/s10787-012-0119-7

中图分类号：

学科分类号：

摘要：

It is customary for physicians and surgeons to recommend treatments that have the highest probability of getting the patient a good outcome. Deciding treatment based on results (outcomes actually achieved) has been advocated for hundreds of years. We are now in an era when practice recommendations are supposed to be based on evidence from randomized controlled trials. There are many defects in relying on RCTs which are reviewed in this article. Advantages of observational studies are outlined, and the importance of assessing one's actual results when applying a treatment based on controlled trial evidence is set out.© Springer Basel AG 2012.

引用

页码：187 / 193

页数：6

共 41 条

[1]

Armitage J., Randomized trials remain essential and are not overrated, J Roy Coll Phys Edin, 41, pp. 126-131, (2011)

[2]

Ata B., Tan S.L., Shehata F., Holzer H., Buckett W., A Systematic Review of Intravenous Immunoglobulin For the Treatment of Unexplained Recurrent Miscarriage, 2010, (2011)

[3]

Benson K., Hartz A.J., A comparison of observational studies and randomized, controlled trials, New England Journal of Medicine, 342, 25, pp. 1878-1886, (2000)

[4]

Bohluis J., Schmidlin K., Brillant C., Schwarzer G., Trelle S., Seidenfield J., Zeahlen M., Clarke M., Weingart O., Kluge S., Piper M., Rades D., Steensma D.P., Djelbegovic B., Fey M.F., Ray-Coquard I., Machtay M., Moebus V., Thomas G., Untch M., Schumacher M., Egger M., Engert A., Recombinant human erythropoesisstimulating agents and mortality in patients with cancer: A metaanalysis of randomized trials, Lancet, 373, pp. 1532-1542, (2009)

[5]

Buchanan W.W., Kean W.F., Rheumatoid arthritis as seen through long-distance spectacles, Inflammopharmacology, 9, 1-2, pp. 3-22, (2001)

[6]

Buchanan W.W., Kean W.F., Rheumatoid arthritis: Beyond the lymphocyte, J Rheumatol, 28, pp. 691-693, (2001)

[7]

Buchanan W., Kean W.F., Clinical judgement and evidence-based medicine, Joint Bone Spine, 68, 5, pp. 370-372, (2001)

[8]

Buchanan W.W., Kean W.F., Evidence based medicine: The median is not the message, Journal of Rheumatology, 28, 11, pp. 2371-2372, (2001)

[9]

Clark D.A., Is paternal leukocyte immunotherapy indicated ?, Informa Healthcare, pp. 179-184, (2007)

[10]

Clark D.A., Immunological factors in pregnancy wastage: Fact or fiction, American Journal of Reproductive Immunology, 59, 4, pp. 277-300, (2008)

← 1 2 3 4 5 →